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Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma

Glycosylation is an important posttranslational modification of proteins, and it has a profound influence on diverse life processes. An abnormal polysaccharide structure and mutation of the glycosylation pathway are closely correlated with human cancer progression. Glycoproteins such as EGFR, E-cadh...

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Autores principales: Liao, Chengcheng, An, Jiaxing, Tan, Zhangxue, Xu, Fangping, Liu, Jianguo, Wang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847636/
https://www.ncbi.nlm.nih.gov/pubmed/33531990
http://dx.doi.org/10.7150/jca.51604
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author Liao, Chengcheng
An, Jiaxing
Tan, Zhangxue
Xu, Fangping
Liu, Jianguo
Wang, Qian
author_facet Liao, Chengcheng
An, Jiaxing
Tan, Zhangxue
Xu, Fangping
Liu, Jianguo
Wang, Qian
author_sort Liao, Chengcheng
collection PubMed
description Glycosylation is an important posttranslational modification of proteins, and it has a profound influence on diverse life processes. An abnormal polysaccharide structure and mutation of the glycosylation pathway are closely correlated with human cancer progression. Glycoproteins such as EGFR, E-cadherin, CD44, PD-1/PD-L1, B7-H3 and Muc1 play important roles in the progression of head and neck squamous cell carcinoma (HNSCC), and their levels of glycosylation and changes in glycosyl structure are closely linked to HNSCC progression and malignant transformation. The regulation of protein glycosylation in HNSCC provides potential strategies to control cancer stem cell (CSC) subgroup expansion, epithelial-mesenchymal transition (EMT), tumor-related immunity escape and autophagy. Glycoproteins with altered glycosylation can be used as biomarkers for the early diagnosis, monitoring and prognostication of HNSCC. However, the glycobiology of cancer is still a new field that needs to be deeply studied, especially in HNSCC.
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spelling pubmed-78476362021-02-01 Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma Liao, Chengcheng An, Jiaxing Tan, Zhangxue Xu, Fangping Liu, Jianguo Wang, Qian J Cancer Review Glycosylation is an important posttranslational modification of proteins, and it has a profound influence on diverse life processes. An abnormal polysaccharide structure and mutation of the glycosylation pathway are closely correlated with human cancer progression. Glycoproteins such as EGFR, E-cadherin, CD44, PD-1/PD-L1, B7-H3 and Muc1 play important roles in the progression of head and neck squamous cell carcinoma (HNSCC), and their levels of glycosylation and changes in glycosyl structure are closely linked to HNSCC progression and malignant transformation. The regulation of protein glycosylation in HNSCC provides potential strategies to control cancer stem cell (CSC) subgroup expansion, epithelial-mesenchymal transition (EMT), tumor-related immunity escape and autophagy. Glycoproteins with altered glycosylation can be used as biomarkers for the early diagnosis, monitoring and prognostication of HNSCC. However, the glycobiology of cancer is still a new field that needs to be deeply studied, especially in HNSCC. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7847636/ /pubmed/33531990 http://dx.doi.org/10.7150/jca.51604 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liao, Chengcheng
An, Jiaxing
Tan, Zhangxue
Xu, Fangping
Liu, Jianguo
Wang, Qian
Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title_full Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title_fullStr Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title_short Changes in Protein Glycosylation in Head and Neck Squamous Cell Carcinoma
title_sort changes in protein glycosylation in head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847636/
https://www.ncbi.nlm.nih.gov/pubmed/33531990
http://dx.doi.org/10.7150/jca.51604
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