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miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance

Increasing evidence shows that liver tumor-initiating cells (T-ICs) closely associated with the progression, metastasis, recurrence and chemo-resistance of hepatocellular carcinoma (HCC). However, the underlying mechanism for the propagation of liver T-ICs remains unclear. Here we show that miR-361-...

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Autores principales: Qu, Shuping, Zhang, Xiaobing, Wu, Yue, Li, HengYu, Zhai, Jian, Wu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847642/
https://www.ncbi.nlm.nih.gov/pubmed/33531993
http://dx.doi.org/10.7150/jca.52395
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author Qu, Shuping
Zhang, Xiaobing
Wu, Yue
Li, HengYu
Zhai, Jian
Wu, Dong
author_facet Qu, Shuping
Zhang, Xiaobing
Wu, Yue
Li, HengYu
Zhai, Jian
Wu, Dong
author_sort Qu, Shuping
collection PubMed
description Increasing evidence shows that liver tumor-initiating cells (T-ICs) closely associated with the progression, metastasis, recurrence and chemo-resistance of hepatocellular carcinoma (HCC). However, the underlying mechanism for the propagation of liver T-ICs remains unclear. Here we show that miR-361-3p is upregulated in liver T-ICs. Knockdown of miR-361-3p impairs the self-renewal and tumorigenicity liver T-ICs. Conversely, forced miR-361-3p expression enhances the self-renewal and tumorigenicity liver T-ICs. Mechanistically, miR-361-3p directly targets SOX1 via binding its 3'-UTR in liver T-ICs. Moreover, miR-361-3p knockdown hepatoma cells are more sensitive to cisplatin or sorafenib treatment. Clinical cohort analysis demonstrates that miR-361-3p low HCC patients are benefited from TACE (transcatheter arterial chemoembolization) or sorafenib treatment. In conclusion, our findings revealed the crucial role of the miR-361-3p in liver T-IC expansion and TACE or sorafenib response, rendering miR-361-3p an optimal target for the prevention and intervention in HCC.
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spelling pubmed-78476422021-02-01 miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance Qu, Shuping Zhang, Xiaobing Wu, Yue Li, HengYu Zhai, Jian Wu, Dong J Cancer Research Paper Increasing evidence shows that liver tumor-initiating cells (T-ICs) closely associated with the progression, metastasis, recurrence and chemo-resistance of hepatocellular carcinoma (HCC). However, the underlying mechanism for the propagation of liver T-ICs remains unclear. Here we show that miR-361-3p is upregulated in liver T-ICs. Knockdown of miR-361-3p impairs the self-renewal and tumorigenicity liver T-ICs. Conversely, forced miR-361-3p expression enhances the self-renewal and tumorigenicity liver T-ICs. Mechanistically, miR-361-3p directly targets SOX1 via binding its 3'-UTR in liver T-ICs. Moreover, miR-361-3p knockdown hepatoma cells are more sensitive to cisplatin or sorafenib treatment. Clinical cohort analysis demonstrates that miR-361-3p low HCC patients are benefited from TACE (transcatheter arterial chemoembolization) or sorafenib treatment. In conclusion, our findings revealed the crucial role of the miR-361-3p in liver T-IC expansion and TACE or sorafenib response, rendering miR-361-3p an optimal target for the prevention and intervention in HCC. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7847642/ /pubmed/33531993 http://dx.doi.org/10.7150/jca.52395 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Qu, Shuping
Zhang, Xiaobing
Wu, Yue
Li, HengYu
Zhai, Jian
Wu, Dong
miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title_full miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title_fullStr miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title_full_unstemmed miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title_short miR-361-3p Regulates Liver Tumor-initiating Cells Expansion and Chemo-resistance
title_sort mir-361-3p regulates liver tumor-initiating cells expansion and chemo-resistance
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847642/
https://www.ncbi.nlm.nih.gov/pubmed/33531993
http://dx.doi.org/10.7150/jca.52395
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