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Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions

Background: Gallbladder lesions have become more common nowadays. But there is limited evidence-based guidance on surveillance of these patients for malignancy. Predicting malignancy could help clinicians better manage this condition and improve the prognosis. We evaluated the independent and joint...

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Autores principales: Deng, Zheng, Xuan, Yan, Li, Xinxing, Crawford, William J, Yuan, Zhiqing, Chen, Zhoukan, Brooks, Anastasia, Song, Yanyan, Wang, Haolu, Liang, Xiaowen, Chen, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847661/
https://www.ncbi.nlm.nih.gov/pubmed/33531998
http://dx.doi.org/10.7150/jca.54617
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author Deng, Zheng
Xuan, Yan
Li, Xinxing
Crawford, William J
Yuan, Zhiqing
Chen, Zhoukan
Brooks, Anastasia
Song, Yanyan
Wang, Haolu
Liang, Xiaowen
Chen, Tao
author_facet Deng, Zheng
Xuan, Yan
Li, Xinxing
Crawford, William J
Yuan, Zhiqing
Chen, Zhoukan
Brooks, Anastasia
Song, Yanyan
Wang, Haolu
Liang, Xiaowen
Chen, Tao
author_sort Deng, Zheng
collection PubMed
description Background: Gallbladder lesions have become more common nowadays. But there is limited evidence-based guidance on surveillance of these patients for malignancy. Predicting malignancy could help clinicians better manage this condition and improve the prognosis. We evaluated the independent and joint effects of metabolic syndrome components on the risk of malignancy among patients with gallbladder lesions. Methods: Using a multicenter database, consecutive patients with pathologically confirmed gallbladder lesions between 2012 and 2019 were identified. Univariate and multivariate logistic regression analyses were used to evaluate the effects of metabolic syndrome components (diabetes, hypertension, dyslipidemia and obesity) as additive or combined indicators for the risk of malignancy. Unadjusted and adjusted odds ratios were calculated. Results: Of the 625 patients, 567 patients were identified with benign gallbladder lesions and 58 patients with gallbladder cancer (GBC). GBC group had less obesity but more dyslipidemia. Among all metabolic syndrome components, only dyslipidemia was significantly associated with GBC (odds ratio 2.674, 95% confidence interval 1.173-6.094). Dyslipidemia was an independent risk factor for malignancy (adjusted odds ratio 2.164, 95% confidence interval 1.165-4.021), regardless of whether the other risk factors and metabolic syndrome components were combined. Patients with decreased high-density lipoprotein had 3.035-fold higher risk of malignancy (adjusted odds ratio 3.035, 95% confidence interval 1.645-5.600). Conclusions: Dyslipidemia is associated with a 2.674-fold increase in the risk of malignancy in patients with gallbladder lesions. Dyslipidemia is an independent risk factor for malignancy, regardless of the presence of the other risk factors and metabolic syndrome components.
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spelling pubmed-78476612021-02-01 Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions Deng, Zheng Xuan, Yan Li, Xinxing Crawford, William J Yuan, Zhiqing Chen, Zhoukan Brooks, Anastasia Song, Yanyan Wang, Haolu Liang, Xiaowen Chen, Tao J Cancer Research Paper Background: Gallbladder lesions have become more common nowadays. But there is limited evidence-based guidance on surveillance of these patients for malignancy. Predicting malignancy could help clinicians better manage this condition and improve the prognosis. We evaluated the independent and joint effects of metabolic syndrome components on the risk of malignancy among patients with gallbladder lesions. Methods: Using a multicenter database, consecutive patients with pathologically confirmed gallbladder lesions between 2012 and 2019 were identified. Univariate and multivariate logistic regression analyses were used to evaluate the effects of metabolic syndrome components (diabetes, hypertension, dyslipidemia and obesity) as additive or combined indicators for the risk of malignancy. Unadjusted and adjusted odds ratios were calculated. Results: Of the 625 patients, 567 patients were identified with benign gallbladder lesions and 58 patients with gallbladder cancer (GBC). GBC group had less obesity but more dyslipidemia. Among all metabolic syndrome components, only dyslipidemia was significantly associated with GBC (odds ratio 2.674, 95% confidence interval 1.173-6.094). Dyslipidemia was an independent risk factor for malignancy (adjusted odds ratio 2.164, 95% confidence interval 1.165-4.021), regardless of whether the other risk factors and metabolic syndrome components were combined. Patients with decreased high-density lipoprotein had 3.035-fold higher risk of malignancy (adjusted odds ratio 3.035, 95% confidence interval 1.645-5.600). Conclusions: Dyslipidemia is associated with a 2.674-fold increase in the risk of malignancy in patients with gallbladder lesions. Dyslipidemia is an independent risk factor for malignancy, regardless of the presence of the other risk factors and metabolic syndrome components. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7847661/ /pubmed/33531998 http://dx.doi.org/10.7150/jca.54617 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Deng, Zheng
Xuan, Yan
Li, Xinxing
Crawford, William J
Yuan, Zhiqing
Chen, Zhoukan
Brooks, Anastasia
Song, Yanyan
Wang, Haolu
Liang, Xiaowen
Chen, Tao
Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title_full Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title_fullStr Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title_full_unstemmed Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title_short Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
title_sort effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847661/
https://www.ncbi.nlm.nih.gov/pubmed/33531998
http://dx.doi.org/10.7150/jca.54617
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