Cargando…

Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse

Rationale: The activity of aldehyde dehydrogenase 7A1 (ALDH7A1), an enzyme that catalyzes the lipid peroxidation of fatty aldehydes was found to be upregulated in pancreatic ductal adenocarcinoma (PDAC). ALDH7A1 knockdown significantly reduced tumor formation in PDAC. We raised a question how ALDH7A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jae-Seon, Lee, Ho, Woo, Sang Myung, Jang, Hyonchol, Jeon, Yoon, Kim, Hee Yeon, Song, Jaewhan, Lee, Woo Jin, Hong, Eun Kyung, Park, Sang-Jae, Han, Sung-Sik, Kim, Soo-Youl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847681/ https://www.ncbi.nlm.nih.gov/pubmed/33537098 http://dx.doi.org/10.7150/thno.53935

Ejemplares similares

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling
por: Lee, Jae-Seon, et al.
Publicado: (2020)

The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer
por: Lee, Seon-Hyeong, et al.
Publicado: (2020)

Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma
por: Ryu, Kum Hei, et al.
Publicado: (2023)

Reply to Krupenko et al., Comment on “Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382”
por: Lee, Seon-Hyeong, et al.
Publicado: (2021)

835. Comparison of the outcomes of patients with KPC and NDM-1-producing Enterobacteriaceae
por: Seo, Hyeonji, et al.
Publicado: (2020)

Pancreaticoduodenectomy of Pancreatic Ductal Adenocarcinoma in the Elderly
por: Kang, Chang Moo, et al.
Publicado: (2007)

Different Biological Action of Oleic Acid in ALDH(high) and ALDH(low) Subpopulations Separated from Ductal Carcinoma In Situ of Breast Cancer
por: Kim, Hoe Suk, et al.
Publicado: (2016)

Prognostic Significance of Maspin in Pancreatic Ductal Adenocarcinoma
por: Lim, Yun Jeong, et al.
Publicado: (2004)

Arterial resection during pancreatectomy for pancreatic ductal adenocarcinoma with arterial invasion: A single-center experience with 109 patients
por: Kwon, Jaewoo, et al.
Publicado: (2020)

Enhancement parameters of contrast-enhanced computed tomography for pancreatic ductal adenocarcinoma: Correlation with pathologic grading
por: Seo, Woorim, et al.
Publicado: (2020)

Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC
por: Lee, Soohyun, et al.
Publicado: (2018)

Laparoscopic pancreaticoduodenectomy in pancreatic ductal adenocarcinoma
por: Choi, Munseok, et al.
Publicado: (2021)

Is Laparoscopic Pancreaticoduodenectomy Feasible for Pancreatic Ductal Adenocarcinoma?
por: Kang, Chang Moo, et al.
Publicado: (2020)

Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
por: Thakur, Gitika, et al.
Publicado: (2021)

The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma
por: Park, Joo Kyung, et al.
Publicado: (2016)

SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma
por: Lee, Jang-Seok, et al.
Publicado: (2020)

Synchronous Pancreatic Ductal Adenocarcinomas Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Biopsy
por: Goong, Hyeon Jeong, et al.
Publicado: (2015)

Prognosis and Clinical Characteristics of Patients with Pancreatic Ductal Adenocarcinoma Diagnosed by Endoscopic Ultrasonography but Indeterminate on Computed Tomography
por: Ko, Sung Woo, et al.
Publicado: (2022)

Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
por: Jeon, Ji Hoon, et al.
Publicado: (2016)

New Morphological Features for Grading Pancreatic Ductal Adenocarcinomas
por: Song, Jae-Won, et al.
Publicado: (2013)

Prognostic Value of VEGF in Human Pancreatic Ductal Adenocarcinoma
por: Lim, Yun Jeong, et al.
Publicado: (2004)

Corrigendum: Prognosis and Clinical Characteristics of Patients with Pancreatic Ductal Adenocarcinoma Diagnosed by Endoscopic Ultrasonography but Indeterminate on Computed Tomography
por: Ko, Sung Woo, et al.
Publicado: (2022)

Serum interleukin-6 is associated with pancreatic ductal adenocarcinoma progression pattern
por: Kim, Hyoung Woo, et al.
Publicado: (2017)

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC
por: Lee, Jae-Seon, et al.
Publicado: (2016)

The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice
por: Kim, Hack-Lyoung, et al.
Publicado: (2014)

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
por: Lee, Jun Hwa, et al.
Publicado: (2018)

Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma
por: Goh, Tae Sik, et al.
Publicado: (2019)

Initial Metastatic Site as a Prognostic Factor in Patients With Stage IV Pancreatic Ductal Adenocarcinoma
por: Kim, Hyoung Woo, et al.
Publicado: (2015)

Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma
por: Lee, Seon-Hyeong, et al.
Publicado: (2020)

Validation of the eighth edition of the American Joint Committee on Cancer staging system and proposal of an improved staging system for pancreatic ductal adenocarcinoma
por: Park, Min Young, et al.
Publicado: (2019)

Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis
por: Lee, Jae Ho, et al.
Publicado: (2017)

Toward angiogenesis of implanted bio-artificial liver using scaffolds with type I collagen and adipose tissue-derived stem cells
por: Lee, Jae Geun, et al.
Publicado: (2015)

Obesity is associated with improved postoperative overall survival, independent of skeletal muscle mass in lung adenocarcinoma
por: Lee, Ji Hyun, et al.
Publicado: (2022)

Bioinformatic Exploration for Prognostic Significance of Sphingolipid Metabolism-Related Genes in Invasive Ductal Carcinoma Using the Cancer Genome Atlas Cohort
por: Kim, Su-Jeong, et al.
Publicado: (2021)

Biomarker Panel for the Diagnosis of Pancreatic Ductal Adenocarcinoma
por: Kim, Hongbeom, et al.
Publicado: (2020)

Effectiveness and feasibility of concurrent chemoradiotherapy using simultaneous integrated boost-intensity modulated radiotherapy with and without induction chemotherapy for locally advanced pancreatic cancer
por: Oh, Eun Sang, et al.
Publicado: (2018)

Association between Metformin Use and Clinical Outcomes Following Pancreaticoduodenectomy in Patients with Type 2 Diabetes and Pancreatic Ductal Adenocarcinoma
por: Yoo, Daegwang, et al.
Publicado: (2020)

Validation of IL-7R as an Immunological Biomarker for Human Pancreatic Ductal Adenocarcinoma
por: Jang, Sung-Ill, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r8pb616nmekgpsf4mf95vmg9m1