Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis

Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influenc...

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Autores principales: Li, Jingyi, Mo, Chunfen, Guo, Yifan, Zhang, Bowen, Feng, Xiao, Si, Qiuyue, Wu, Xiaobo, Zhao, Zhe, Gong, Lixin, He, Dan, Shao, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847688/
https://www.ncbi.nlm.nih.gov/pubmed/33537091
http://dx.doi.org/10.7150/thno.45889
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author Li, Jingyi
Mo, Chunfen
Guo, Yifan
Zhang, Bowen
Feng, Xiao
Si, Qiuyue
Wu, Xiaobo
Zhao, Zhe
Gong, Lixin
He, Dan
Shao, Jichun
author_facet Li, Jingyi
Mo, Chunfen
Guo, Yifan
Zhang, Bowen
Feng, Xiao
Si, Qiuyue
Wu, Xiaobo
Zhao, Zhe
Gong, Lixin
He, Dan
Shao, Jichun
author_sort Li, Jingyi
collection PubMed
description Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
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spelling pubmed-78476882021-02-02 Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis Li, Jingyi Mo, Chunfen Guo, Yifan Zhang, Bowen Feng, Xiao Si, Qiuyue Wu, Xiaobo Zhao, Zhe Gong, Lixin He, Dan Shao, Jichun Theranostics Review Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis. Ivyspring International Publisher 2021-01-19 /pmc/articles/PMC7847688/ /pubmed/33537091 http://dx.doi.org/10.7150/thno.45889 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Li, Jingyi
Mo, Chunfen
Guo, Yifan
Zhang, Bowen
Feng, Xiao
Si, Qiuyue
Wu, Xiaobo
Zhao, Zhe
Gong, Lixin
He, Dan
Shao, Jichun
Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title_full Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title_fullStr Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title_full_unstemmed Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title_short Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
title_sort roles of peptidyl-prolyl isomerase pin1 in disease pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847688/
https://www.ncbi.nlm.nih.gov/pubmed/33537091
http://dx.doi.org/10.7150/thno.45889
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