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Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke

Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The e...

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Autores principales: Mantell, Kathleen E., Sutter, Ellen N., Shirinpour, Sina, Nemanich, Samuel T., Lench, Daniel H., Gillick, Bernadette T., Opitz, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847946/
https://www.ncbi.nlm.nih.gov/pubmed/33516935
http://dx.doi.org/10.1016/j.nicl.2021.102563
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author Mantell, Kathleen E.
Sutter, Ellen N.
Shirinpour, Sina
Nemanich, Samuel T.
Lench, Daniel H.
Gillick, Bernadette T.
Opitz, Alexander
author_facet Mantell, Kathleen E.
Sutter, Ellen N.
Shirinpour, Sina
Nemanich, Samuel T.
Lench, Daniel H.
Gillick, Bernadette T.
Opitz, Alexander
author_sort Mantell, Kathleen E.
collection PubMed
description Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The effect of TMS-induced electric fields has not been explored in children with stroke lesions. Here, we used finite element method (FEM) modeling to study how the electric field strength is affected by the presence of a lesion. We created individual realistic head models from MRIs (n = 6) of children with unilateral cerebral palsy due to perinatal stroke. We conducted TMS electric field simulations for coil locations over lesioned and non-lesioned hemispheres. We found that the presence of a lesion can strongly affect the electric field distribution. On the group level, the mean electric field strength did not differ between lesioned and non-lesioned hemispheres but exhibited a greater variability in the lesioned hemisphere. Other factors such as coil-to-cortex distance have a strong influence on the TMS electric field even in the presence of lesions. Our study has important implications for the delivery of TMS in children with brain lesions with respect to TMS dosing and coil placement.
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spelling pubmed-78479462021-02-04 Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke Mantell, Kathleen E. Sutter, Ellen N. Shirinpour, Sina Nemanich, Samuel T. Lench, Daniel H. Gillick, Bernadette T. Opitz, Alexander Neuroimage Clin Regular Article Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The effect of TMS-induced electric fields has not been explored in children with stroke lesions. Here, we used finite element method (FEM) modeling to study how the electric field strength is affected by the presence of a lesion. We created individual realistic head models from MRIs (n = 6) of children with unilateral cerebral palsy due to perinatal stroke. We conducted TMS electric field simulations for coil locations over lesioned and non-lesioned hemispheres. We found that the presence of a lesion can strongly affect the electric field distribution. On the group level, the mean electric field strength did not differ between lesioned and non-lesioned hemispheres but exhibited a greater variability in the lesioned hemisphere. Other factors such as coil-to-cortex distance have a strong influence on the TMS electric field even in the presence of lesions. Our study has important implications for the delivery of TMS in children with brain lesions with respect to TMS dosing and coil placement. Elsevier 2021-01-13 /pmc/articles/PMC7847946/ /pubmed/33516935 http://dx.doi.org/10.1016/j.nicl.2021.102563 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Mantell, Kathleen E.
Sutter, Ellen N.
Shirinpour, Sina
Nemanich, Samuel T.
Lench, Daniel H.
Gillick, Bernadette T.
Opitz, Alexander
Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title_full Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title_fullStr Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title_full_unstemmed Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title_short Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
title_sort evaluating transcranial magnetic stimulation (tms) induced electric fields in pediatric stroke
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847946/
https://www.ncbi.nlm.nih.gov/pubmed/33516935
http://dx.doi.org/10.1016/j.nicl.2021.102563
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