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Aging as a Context for the Role of Inflammation in Depressive Symptoms

Inflammation has been implicated in the pathogenesis and maintenance of depressive symptoms. The role of inflammation in depressive symptomatology may be complex, varying within endophenotypes and across the lifespan. Aging is associated with myriad changes in the structure and function of the brain...

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Autores principales: Straka, Kelci, Tran, Mai-Lan, Millwood, Summer, Swanson, James, Kuhlman, Kate Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848015/
https://www.ncbi.nlm.nih.gov/pubmed/33536949
http://dx.doi.org/10.3389/fpsyt.2020.605347
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author Straka, Kelci
Tran, Mai-Lan
Millwood, Summer
Swanson, James
Kuhlman, Kate Ryan
author_facet Straka, Kelci
Tran, Mai-Lan
Millwood, Summer
Swanson, James
Kuhlman, Kate Ryan
author_sort Straka, Kelci
collection PubMed
description Inflammation has been implicated in the pathogenesis and maintenance of depressive symptoms. The role of inflammation in depressive symptomatology may be complex, varying within endophenotypes and across the lifespan. Aging is associated with myriad changes in the structure and function of the brain. Yet, little attention has been given to the role of inflammation in depressive symptoms within a lifespan developmental framework. In this study, we examined whether the association between inflammation and depressive symptom domains varied by age. Participants were a community sample of individuals (N = 2,077, Range = 30–84) who participated in the Biomarker projects of the MIDUS2, MIDUS Refresher, or the MIDJA study. Inflammation was indexed by two inflammatory markers consistently implicated in depressed individuals, interleukin 6 (IL-6) and C-reactive protein (CRP), measured in blood. Depressive symptom domains, including depressed affect, anhedonia, somatic complaints, and interpersonal problems, were reported via the Center for Epidemiologic Studies—Depression Scale (CES-D). Inflammatory markers were associated with more somatic complaints, more interpersonal problems, and less anhedonia. Age moderated the relationship between inflammatory markers and two depressive symptom subscales. Specifically, the positive association between inflammation and somatic complaints and the negative association between inflammation and anhedonia increased with age. These observations offer preliminary evidence from a large community sample that aging may be an important context for the role of inflammatory signaling in different aspects of psychological and behavioral well-being.
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spelling pubmed-78480152021-02-02 Aging as a Context for the Role of Inflammation in Depressive Symptoms Straka, Kelci Tran, Mai-Lan Millwood, Summer Swanson, James Kuhlman, Kate Ryan Front Psychiatry Psychiatry Inflammation has been implicated in the pathogenesis and maintenance of depressive symptoms. The role of inflammation in depressive symptomatology may be complex, varying within endophenotypes and across the lifespan. Aging is associated with myriad changes in the structure and function of the brain. Yet, little attention has been given to the role of inflammation in depressive symptoms within a lifespan developmental framework. In this study, we examined whether the association between inflammation and depressive symptom domains varied by age. Participants were a community sample of individuals (N = 2,077, Range = 30–84) who participated in the Biomarker projects of the MIDUS2, MIDUS Refresher, or the MIDJA study. Inflammation was indexed by two inflammatory markers consistently implicated in depressed individuals, interleukin 6 (IL-6) and C-reactive protein (CRP), measured in blood. Depressive symptom domains, including depressed affect, anhedonia, somatic complaints, and interpersonal problems, were reported via the Center for Epidemiologic Studies—Depression Scale (CES-D). Inflammatory markers were associated with more somatic complaints, more interpersonal problems, and less anhedonia. Age moderated the relationship between inflammatory markers and two depressive symptom subscales. Specifically, the positive association between inflammation and somatic complaints and the negative association between inflammation and anhedonia increased with age. These observations offer preliminary evidence from a large community sample that aging may be an important context for the role of inflammatory signaling in different aspects of psychological and behavioral well-being. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848015/ /pubmed/33536949 http://dx.doi.org/10.3389/fpsyt.2020.605347 Text en Copyright © 2021 Straka, Tran, Millwood, Swanson and Kuhlman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Straka, Kelci
Tran, Mai-Lan
Millwood, Summer
Swanson, James
Kuhlman, Kate Ryan
Aging as a Context for the Role of Inflammation in Depressive Symptoms
title Aging as a Context for the Role of Inflammation in Depressive Symptoms
title_full Aging as a Context for the Role of Inflammation in Depressive Symptoms
title_fullStr Aging as a Context for the Role of Inflammation in Depressive Symptoms
title_full_unstemmed Aging as a Context for the Role of Inflammation in Depressive Symptoms
title_short Aging as a Context for the Role of Inflammation in Depressive Symptoms
title_sort aging as a context for the role of inflammation in depressive symptoms
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848015/
https://www.ncbi.nlm.nih.gov/pubmed/33536949
http://dx.doi.org/10.3389/fpsyt.2020.605347
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