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Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immuno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848017/ https://www.ncbi.nlm.nih.gov/pubmed/33537327 http://dx.doi.org/10.3389/fmed.2020.601854 |
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author | Moreno, María de Lourdes Sánchez-Muñoz, Diego Sanders, David Rodríguez-Herrera, Alfonso Sousa, Carolina |
author_facet | Moreno, María de Lourdes Sánchez-Muñoz, Diego Sanders, David Rodríguez-Herrera, Alfonso Sousa, Carolina |
author_sort | Moreno, María de Lourdes |
collection | PubMed |
description | Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immunogenic peptides (GIP) in urine. This study assessed urine GIP to verify whether RCD patients could be reclassified as “exposed to gluten.” Three out of four RCD patients had at least two positive-GIP urine samples in a follow-up of 3 months, demonstrating gluten exposure. Urine GIP may enable the accurate RCD verification and decrease overuse of immunosuppressants, increasing cost effectiveness. |
format | Online Article Text |
id | pubmed-7848017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78480172021-02-02 Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker Moreno, María de Lourdes Sánchez-Muñoz, Diego Sanders, David Rodríguez-Herrera, Alfonso Sousa, Carolina Front Med (Lausanne) Medicine Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immunogenic peptides (GIP) in urine. This study assessed urine GIP to verify whether RCD patients could be reclassified as “exposed to gluten.” Three out of four RCD patients had at least two positive-GIP urine samples in a follow-up of 3 months, demonstrating gluten exposure. Urine GIP may enable the accurate RCD verification and decrease overuse of immunosuppressants, increasing cost effectiveness. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848017/ /pubmed/33537327 http://dx.doi.org/10.3389/fmed.2020.601854 Text en Copyright © 2021 Moreno, Sánchez-Muñoz, Sanders, Rodríguez-Herrera and Sousa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Moreno, María de Lourdes Sánchez-Muñoz, Diego Sanders, David Rodríguez-Herrera, Alfonso Sousa, Carolina Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title | Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title_full | Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title_fullStr | Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title_full_unstemmed | Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title_short | Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker |
title_sort | verifying diagnosis of refractory celiac disease with urine gluten immunogenic peptides as biomarker |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848017/ https://www.ncbi.nlm.nih.gov/pubmed/33537327 http://dx.doi.org/10.3389/fmed.2020.601854 |
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