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Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker

Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immuno...

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Autores principales: Moreno, María de Lourdes, Sánchez-Muñoz, Diego, Sanders, David, Rodríguez-Herrera, Alfonso, Sousa, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848017/
https://www.ncbi.nlm.nih.gov/pubmed/33537327
http://dx.doi.org/10.3389/fmed.2020.601854
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author Moreno, María de Lourdes
Sánchez-Muñoz, Diego
Sanders, David
Rodríguez-Herrera, Alfonso
Sousa, Carolina
author_facet Moreno, María de Lourdes
Sánchez-Muñoz, Diego
Sanders, David
Rodríguez-Herrera, Alfonso
Sousa, Carolina
author_sort Moreno, María de Lourdes
collection PubMed
description Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immunogenic peptides (GIP) in urine. This study assessed urine GIP to verify whether RCD patients could be reclassified as “exposed to gluten.” Three out of four RCD patients had at least two positive-GIP urine samples in a follow-up of 3 months, demonstrating gluten exposure. Urine GIP may enable the accurate RCD verification and decrease overuse of immunosuppressants, increasing cost effectiveness.
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spelling pubmed-78480172021-02-02 Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker Moreno, María de Lourdes Sánchez-Muñoz, Diego Sanders, David Rodríguez-Herrera, Alfonso Sousa, Carolina Front Med (Lausanne) Medicine Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immunogenic peptides (GIP) in urine. This study assessed urine GIP to verify whether RCD patients could be reclassified as “exposed to gluten.” Three out of four RCD patients had at least two positive-GIP urine samples in a follow-up of 3 months, demonstrating gluten exposure. Urine GIP may enable the accurate RCD verification and decrease overuse of immunosuppressants, increasing cost effectiveness. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848017/ /pubmed/33537327 http://dx.doi.org/10.3389/fmed.2020.601854 Text en Copyright © 2021 Moreno, Sánchez-Muñoz, Sanders, Rodríguez-Herrera and Sousa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Moreno, María de Lourdes
Sánchez-Muñoz, Diego
Sanders, David
Rodríguez-Herrera, Alfonso
Sousa, Carolina
Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title_full Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title_fullStr Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title_full_unstemmed Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title_short Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker
title_sort verifying diagnosis of refractory celiac disease with urine gluten immunogenic peptides as biomarker
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848017/
https://www.ncbi.nlm.nih.gov/pubmed/33537327
http://dx.doi.org/10.3389/fmed.2020.601854
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