Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis

A synthetic peptide, K-PLP, consisting of 11-unit poly-lysine (K11) linked via polyethylene glycol (PEG) to proteolipid protein epitope (PLP) was synthesized, characterized, and evaluated for efficacy in ameliorating experimental autoimmune encephalomyelitis (EAE) induced by PLP. K-PLP was designed...

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Detalles Bibliográficos
Autores principales: Song, Jimmy Y., Griffin, J. Daniel, Larson, Nicholas R., Christopher, Matthew A., Middaugh, C. Russell, Berkland, Cory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848024/
https://www.ncbi.nlm.nih.gov/pubmed/33537031
http://dx.doi.org/10.3389/fimmu.2020.603029

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