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miRNAs and Müller Glia Reprogramming During Retina Regeneration
The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of ke...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848101/ https://www.ncbi.nlm.nih.gov/pubmed/33537319 http://dx.doi.org/10.3389/fcell.2020.632632 |
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author | Konar, Gregory J. Ferguson, Claire Flickinger, Zachary Kent, Matthew R. Patton, James G. |
author_facet | Konar, Gregory J. Ferguson, Claire Flickinger, Zachary Kent, Matthew R. Patton, James G. |
author_sort | Konar, Gregory J. |
collection | PubMed |
description | The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of key factors, altered chromatin accessibility, or inhibition of kinase/signaling cascades, a clearer picture of the key regulatory events that control retina regeneration is emerging. In all cases, Müller glia (MG) serve as an adult retinal stem cell that must be reprogrammed to allow for regeneration, with the end goal being to understand why regenerative pathways are blocked in mammals, but spontaneous in other vertebrates such as zebrafish. miRNAs have emerged as key gene regulatory molecules that control both development and regeneration in vertebrates. Here, we focus on a small subset of miRNAs that control MG reprogramming during retina regeneration and have the potential to serve as therapeutic targets for treatment of visual disorders and damage. |
format | Online Article Text |
id | pubmed-7848101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78481012021-02-02 miRNAs and Müller Glia Reprogramming During Retina Regeneration Konar, Gregory J. Ferguson, Claire Flickinger, Zachary Kent, Matthew R. Patton, James G. Front Cell Dev Biol Cell and Developmental Biology The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of key factors, altered chromatin accessibility, or inhibition of kinase/signaling cascades, a clearer picture of the key regulatory events that control retina regeneration is emerging. In all cases, Müller glia (MG) serve as an adult retinal stem cell that must be reprogrammed to allow for regeneration, with the end goal being to understand why regenerative pathways are blocked in mammals, but spontaneous in other vertebrates such as zebrafish. miRNAs have emerged as key gene regulatory molecules that control both development and regeneration in vertebrates. Here, we focus on a small subset of miRNAs that control MG reprogramming during retina regeneration and have the potential to serve as therapeutic targets for treatment of visual disorders and damage. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848101/ /pubmed/33537319 http://dx.doi.org/10.3389/fcell.2020.632632 Text en Copyright © 2021 Konar, Ferguson, Flickinger, Kent and Patton. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Konar, Gregory J. Ferguson, Claire Flickinger, Zachary Kent, Matthew R. Patton, James G. miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title | miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title_full | miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title_fullStr | miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title_full_unstemmed | miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title_short | miRNAs and Müller Glia Reprogramming During Retina Regeneration |
title_sort | mirnas and müller glia reprogramming during retina regeneration |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848101/ https://www.ncbi.nlm.nih.gov/pubmed/33537319 http://dx.doi.org/10.3389/fcell.2020.632632 |
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