The Complexity of TET2 Functions in Pluripotency and Development

Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Outeiral, Vera, de la Parte, Cristina, Fidalgo, Miguel, Guallar, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848104/
https://www.ncbi.nlm.nih.gov/pubmed/33537318
http://dx.doi.org/10.3389/fcell.2020.630754
_version_ 1783645058281504768
author Garcia-Outeiral, Vera
de la Parte, Cristina
Fidalgo, Miguel
Guallar, Diana
author_facet Garcia-Outeiral, Vera
de la Parte, Cristina
Fidalgo, Miguel
Guallar, Diana
author_sort Garcia-Outeiral, Vera
collection PubMed
description Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes.
format Online
Article
Text
id pubmed-7848104
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78481042021-02-02 The Complexity of TET2 Functions in Pluripotency and Development Garcia-Outeiral, Vera de la Parte, Cristina Fidalgo, Miguel Guallar, Diana Front Cell Dev Biol Cell and Developmental Biology Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848104/ /pubmed/33537318 http://dx.doi.org/10.3389/fcell.2020.630754 Text en Copyright © 2021 Garcia-Outeiral, de la Parte, Fidalgo and Guallar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Garcia-Outeiral, Vera
de la Parte, Cristina
Fidalgo, Miguel
Guallar, Diana
The Complexity of TET2 Functions in Pluripotency and Development
title The Complexity of TET2 Functions in Pluripotency and Development
title_full The Complexity of TET2 Functions in Pluripotency and Development
title_fullStr The Complexity of TET2 Functions in Pluripotency and Development
title_full_unstemmed The Complexity of TET2 Functions in Pluripotency and Development
title_short The Complexity of TET2 Functions in Pluripotency and Development
title_sort complexity of tet2 functions in pluripotency and development
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848104/
https://www.ncbi.nlm.nih.gov/pubmed/33537318
http://dx.doi.org/10.3389/fcell.2020.630754
work_keys_str_mv AT garciaouteiralvera thecomplexityoftet2functionsinpluripotencyanddevelopment
AT delapartecristina thecomplexityoftet2functionsinpluripotencyanddevelopment
AT fidalgomiguel thecomplexityoftet2functionsinpluripotencyanddevelopment
AT guallardiana thecomplexityoftet2functionsinpluripotencyanddevelopment
AT garciaouteiralvera complexityoftet2functionsinpluripotencyanddevelopment
AT delapartecristina complexityoftet2functionsinpluripotencyanddevelopment
AT fidalgomiguel complexityoftet2functionsinpluripotencyanddevelopment
AT guallardiana complexityoftet2functionsinpluripotencyanddevelopment

Ejemplares similares