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Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats

Ischemic lesions could lead to secondary degeneration in remote regions of the brain. However, the spatial distribution of secondary degeneration along with its role in functional deficits is not well understood. In this study, we explored the spatial and connectivity properties of white matter (WM)...

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Autores principales: Li, Zhaoqing, Gao, Huan, Zeng, Pingmei, Jia, Yinhang, Kong, Xueqian, Xu, Kedi, Bai, Ruiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848148/
https://www.ncbi.nlm.nih.gov/pubmed/33536869
http://dx.doi.org/10.3389/fnins.2020.611696
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author Li, Zhaoqing
Gao, Huan
Zeng, Pingmei
Jia, Yinhang
Kong, Xueqian
Xu, Kedi
Bai, Ruiliang
author_facet Li, Zhaoqing
Gao, Huan
Zeng, Pingmei
Jia, Yinhang
Kong, Xueqian
Xu, Kedi
Bai, Ruiliang
author_sort Li, Zhaoqing
collection PubMed
description Ischemic lesions could lead to secondary degeneration in remote regions of the brain. However, the spatial distribution of secondary degeneration along with its role in functional deficits is not well understood. In this study, we explored the spatial and connectivity properties of white matter (WM) secondary degeneration in a focal unilateral sensorimotor cortical ischemia rat model, using advanced microstructure imaging on a 14 T MRI system. Significant axonal degeneration was observed in the ipsilateral external capsule and even remote regions including the contralesional external capsule and corpus callosum. Further fiber tractography analysis revealed that only fibers having direct axonal connections with the primary lesion exhibited a significant degeneration. These results suggest that focal ischemic lesions may induce remote WM degeneration, but limited to fibers tied to the primary lesion. These “direct” fibers mainly represent perilesional, interhemispheric, and subcortical axonal connections. At last, we found that primary lesion volume might be the determining factor of motor function deficits.
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spelling pubmed-78481482021-02-02 Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats Li, Zhaoqing Gao, Huan Zeng, Pingmei Jia, Yinhang Kong, Xueqian Xu, Kedi Bai, Ruiliang Front Neurosci Neuroscience Ischemic lesions could lead to secondary degeneration in remote regions of the brain. However, the spatial distribution of secondary degeneration along with its role in functional deficits is not well understood. In this study, we explored the spatial and connectivity properties of white matter (WM) secondary degeneration in a focal unilateral sensorimotor cortical ischemia rat model, using advanced microstructure imaging on a 14 T MRI system. Significant axonal degeneration was observed in the ipsilateral external capsule and even remote regions including the contralesional external capsule and corpus callosum. Further fiber tractography analysis revealed that only fibers having direct axonal connections with the primary lesion exhibited a significant degeneration. These results suggest that focal ischemic lesions may induce remote WM degeneration, but limited to fibers tied to the primary lesion. These “direct” fibers mainly represent perilesional, interhemispheric, and subcortical axonal connections. At last, we found that primary lesion volume might be the determining factor of motor function deficits. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848148/ /pubmed/33536869 http://dx.doi.org/10.3389/fnins.2020.611696 Text en Copyright © 2021 Li, Gao, Zeng, Jia, Kong, Xu and Bai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Zhaoqing
Gao, Huan
Zeng, Pingmei
Jia, Yinhang
Kong, Xueqian
Xu, Kedi
Bai, Ruiliang
Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title_full Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title_fullStr Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title_full_unstemmed Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title_short Secondary Degeneration of White Matter After Focal Sensorimotor Cortical Ischemic Stroke in Rats
title_sort secondary degeneration of white matter after focal sensorimotor cortical ischemic stroke in rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848148/
https://www.ncbi.nlm.nih.gov/pubmed/33536869
http://dx.doi.org/10.3389/fnins.2020.611696
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