Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative pro...

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Detalles Bibliográficos
Autores principales: Fifel, Karim, Videnovic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848154/
https://www.ncbi.nlm.nih.gov/pubmed/33536872
http://dx.doi.org/10.3389/fnins.2020.627330
Descripción
Sumario:Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer’s, Parkinson’s, and Huntington’s diseases.

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