Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative pro...

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Detalles Bibliográficos
Autores principales: Fifel, Karim, Videnovic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848154/
https://www.ncbi.nlm.nih.gov/pubmed/33536872
http://dx.doi.org/10.3389/fnins.2020.627330
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author Fifel, Karim
Videnovic, Aleksandar
author_facet Fifel, Karim
Videnovic, Aleksandar
author_sort Fifel, Karim
collection PubMed
description Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer’s, Parkinson’s, and Huntington’s diseases.
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spelling pubmed-78481542021-02-02 Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update Fifel, Karim Videnovic, Aleksandar Front Neurosci Neuroscience Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer’s, Parkinson’s, and Huntington’s diseases. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7848154/ /pubmed/33536872 http://dx.doi.org/10.3389/fnins.2020.627330 Text en Copyright © 2021 Fifel and Videnovic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fifel, Karim
Videnovic, Aleksandar
Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title_full Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title_fullStr Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title_full_unstemmed Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title_short Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
title_sort circadian and sleep dysfunctions in neurodegenerative disorders—an update
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848154/
https://www.ncbi.nlm.nih.gov/pubmed/33536872
http://dx.doi.org/10.3389/fnins.2020.627330
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