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miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848275/ https://www.ncbi.nlm.nih.gov/pubmed/29690954 http://dx.doi.org/10.3727/096504018X15228863026239 |
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author | Sun, Xiyan Zhang, Chao Cao, Yang Liu, Erbiao |
author_facet | Sun, Xiyan Zhang, Chao Cao, Yang Liu, Erbiao |
author_sort | Sun, Xiyan |
collection | PubMed |
description | miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration, and invasion of melanoma cell by downregulating MYB. |
format | Online Article Text |
id | pubmed-7848275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78482752021-02-16 miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB Sun, Xiyan Zhang, Chao Cao, Yang Liu, Erbiao Oncol Res Article miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration, and invasion of melanoma cell by downregulating MYB. Cognizant Communication Corporation 2019-02-21 /pmc/articles/PMC7848275/ /pubmed/29690954 http://dx.doi.org/10.3727/096504018X15228863026239 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Sun, Xiyan Zhang, Chao Cao, Yang Liu, Erbiao miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title | miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title_full | miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title_fullStr | miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title_full_unstemmed | miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title_short | miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB |
title_sort | mir-150 suppresses tumor growth in melanoma through downregulation of myb |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848275/ https://www.ncbi.nlm.nih.gov/pubmed/29690954 http://dx.doi.org/10.3727/096504018X15228863026239 |
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