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miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB

miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cel...

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Detalles Bibliográficos
Autores principales: Sun, Xiyan, Zhang, Chao, Cao, Yang, Liu, Erbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848275/
https://www.ncbi.nlm.nih.gov/pubmed/29690954
http://dx.doi.org/10.3727/096504018X15228863026239
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author Sun, Xiyan
Zhang, Chao
Cao, Yang
Liu, Erbiao
author_facet Sun, Xiyan
Zhang, Chao
Cao, Yang
Liu, Erbiao
author_sort Sun, Xiyan
collection PubMed
description miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration, and invasion of melanoma cell by downregulating MYB.
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spelling pubmed-78482752021-02-16 miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB Sun, Xiyan Zhang, Chao Cao, Yang Liu, Erbiao Oncol Res Article miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration, and invasion of melanoma cell by downregulating MYB. Cognizant Communication Corporation 2019-02-21 /pmc/articles/PMC7848275/ /pubmed/29690954 http://dx.doi.org/10.3727/096504018X15228863026239 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Sun, Xiyan
Zhang, Chao
Cao, Yang
Liu, Erbiao
miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title_full miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title_fullStr miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title_full_unstemmed miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title_short miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB
title_sort mir-150 suppresses tumor growth in melanoma through downregulation of myb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848275/
https://www.ncbi.nlm.nih.gov/pubmed/29690954
http://dx.doi.org/10.3727/096504018X15228863026239
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