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The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848329/ https://www.ncbi.nlm.nih.gov/pubmed/30982492 http://dx.doi.org/10.3727/096504018X15447833065047 |
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author | Wei, Jie Yan, Yuanliang Chen, Xi Qian, Long Zeng, Shuangshuang Li, Zhi Dai, Shuang Gong, Zhicheng Xu, Zhijie |
author_facet | Wei, Jie Yan, Yuanliang Chen, Xi Qian, Long Zeng, Shuangshuang Li, Zhi Dai, Shuang Gong, Zhicheng Xu, Zhijie |
author_sort | Wei, Jie |
collection | PubMed |
description | Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF-κB activation, suppression of miRNA expression, etc. In addition, the effect of TIG on immune response in cancer patients is summarized for improved immune modulation utilization. However, the clinical use of TPL is often limited by its severe toxicity and water insolubility. Future clinical trials and drug delivery strategies that will evaluate the security and validate the underlying tumor-killing properties of TPL in human NSCLC are also to be discussed. |
format | Online Article Text |
id | pubmed-7848329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78483292021-02-16 The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer Wei, Jie Yan, Yuanliang Chen, Xi Qian, Long Zeng, Shuangshuang Li, Zhi Dai, Shuang Gong, Zhicheng Xu, Zhijie Oncol Res Review Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF-κB activation, suppression of miRNA expression, etc. In addition, the effect of TIG on immune response in cancer patients is summarized for improved immune modulation utilization. However, the clinical use of TPL is often limited by its severe toxicity and water insolubility. Future clinical trials and drug delivery strategies that will evaluate the security and validate the underlying tumor-killing properties of TPL in human NSCLC are also to be discussed. Cognizant Communication Corporation 2019-07-12 /pmc/articles/PMC7848329/ /pubmed/30982492 http://dx.doi.org/10.3727/096504018X15447833065047 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Review Wei, Jie Yan, Yuanliang Chen, Xi Qian, Long Zeng, Shuangshuang Li, Zhi Dai, Shuang Gong, Zhicheng Xu, Zhijie The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title | The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title_full | The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title_fullStr | The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title_full_unstemmed | The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title_short | The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer |
title_sort | roles of plant-derived triptolide on non-small cell lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848329/ https://www.ncbi.nlm.nih.gov/pubmed/30982492 http://dx.doi.org/10.3727/096504018X15447833065047 |
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