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The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer

Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing...

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Autores principales: Wei, Jie, Yan, Yuanliang, Chen, Xi, Qian, Long, Zeng, Shuangshuang, Li, Zhi, Dai, Shuang, Gong, Zhicheng, Xu, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848329/
https://www.ncbi.nlm.nih.gov/pubmed/30982492
http://dx.doi.org/10.3727/096504018X15447833065047
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author Wei, Jie
Yan, Yuanliang
Chen, Xi
Qian, Long
Zeng, Shuangshuang
Li, Zhi
Dai, Shuang
Gong, Zhicheng
Xu, Zhijie
author_facet Wei, Jie
Yan, Yuanliang
Chen, Xi
Qian, Long
Zeng, Shuangshuang
Li, Zhi
Dai, Shuang
Gong, Zhicheng
Xu, Zhijie
author_sort Wei, Jie
collection PubMed
description Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF-κB activation, suppression of miRNA expression, etc. In addition, the effect of TIG on immune response in cancer patients is summarized for improved immune modulation utilization. However, the clinical use of TPL is often limited by its severe toxicity and water insolubility. Future clinical trials and drug delivery strategies that will evaluate the security and validate the underlying tumor-killing properties of TPL in human NSCLC are also to be discussed.
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spelling pubmed-78483292021-02-16 The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer Wei, Jie Yan, Yuanliang Chen, Xi Qian, Long Zeng, Shuangshuang Li, Zhi Dai, Shuang Gong, Zhicheng Xu, Zhijie Oncol Res Review Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF-κB activation, suppression of miRNA expression, etc. In addition, the effect of TIG on immune response in cancer patients is summarized for improved immune modulation utilization. However, the clinical use of TPL is often limited by its severe toxicity and water insolubility. Future clinical trials and drug delivery strategies that will evaluate the security and validate the underlying tumor-killing properties of TPL in human NSCLC are also to be discussed. Cognizant Communication Corporation 2019-07-12 /pmc/articles/PMC7848329/ /pubmed/30982492 http://dx.doi.org/10.3727/096504018X15447833065047 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Review
Wei, Jie
Yan, Yuanliang
Chen, Xi
Qian, Long
Zeng, Shuangshuang
Li, Zhi
Dai, Shuang
Gong, Zhicheng
Xu, Zhijie
The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title_full The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title_fullStr The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title_full_unstemmed The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title_short The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
title_sort roles of plant-derived triptolide on non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848329/
https://www.ncbi.nlm.nih.gov/pubmed/30982492
http://dx.doi.org/10.3727/096504018X15447833065047
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