Cargando…

Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies

BACKGROUND: Since the discovery of the Mik antigen, several studies have described blood incompatibilities unrelated to the AB system in cats. OBJECTIVE: To estimate the prevalence of cats with non‐AB incompatibilities associated with naturally occurring alloantibodies (NOAb), and to begin mapping t...

Descripción completa

Detalles Bibliográficos
Autores principales: Binvel, Marie, Arsenault, Julie, Depré, Boris, Blais, Marie‐Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848337/
https://www.ncbi.nlm.nih.gov/pubmed/33336860
http://dx.doi.org/10.1111/jvim.16010
_version_ 1783645113109446656
author Binvel, Marie
Arsenault, Julie
Depré, Boris
Blais, Marie‐Claude
author_facet Binvel, Marie
Arsenault, Julie
Depré, Boris
Blais, Marie‐Claude
author_sort Binvel, Marie
collection PubMed
description BACKGROUND: Since the discovery of the Mik antigen, several studies have described blood incompatibilities unrelated to the AB system in cats. OBJECTIVE: To estimate the prevalence of cats with non‐AB incompatibilities associated with naturally occurring alloantibodies (NOAb), and to begin mapping the corresponding feline erythrocyte antigens (FEA). ANIMALS: Two hundred and fifty‐eight type A cats. METHODS: Prospectively, cats were evaluated for the presence of NOAb by crossmatching in groups of 4‐6 cats. When NOAb were detected in a cat, its plasma was used as reagent to assess for the presence of the corresponding FEA in all cats included thereafter, and agreement observed between results of this extensive blood typing was evaluated. RESULTS: The chance of detecting incompatibilities by randomly crossmatching 2 cats was 3.9%, which resulted in at least 7% of type A cats having NOAb. Blood typing and agreement analyses performed with 7 newly detected NOAb allowed the identification of 5 presumably distinct FEA. Feline erythrocyte antigens 1 and 5 were most frequent with prevalence of 84% and 96%, respectively. Only FEA 1‐negative status was associated with a higher risk of presenting NOAb; with 16.7% of 42 FEA 1‐negative cats having NOAb compared to 5.1% of 216 FEA 1‐positive cats. CONCLUSIONS AND CLINICAL IMPORTANCE: This study represents a first step of FEA identification outside the AB system. Because of its prevalence and association with NOAb, FEA 1 might correspond to the Mik antigen.
format Online
Article
Text
id pubmed-7848337
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-78483372021-02-05 Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies Binvel, Marie Arsenault, Julie Depré, Boris Blais, Marie‐Claude J Vet Intern Med SMALL ANIMAL BACKGROUND: Since the discovery of the Mik antigen, several studies have described blood incompatibilities unrelated to the AB system in cats. OBJECTIVE: To estimate the prevalence of cats with non‐AB incompatibilities associated with naturally occurring alloantibodies (NOAb), and to begin mapping the corresponding feline erythrocyte antigens (FEA). ANIMALS: Two hundred and fifty‐eight type A cats. METHODS: Prospectively, cats were evaluated for the presence of NOAb by crossmatching in groups of 4‐6 cats. When NOAb were detected in a cat, its plasma was used as reagent to assess for the presence of the corresponding FEA in all cats included thereafter, and agreement observed between results of this extensive blood typing was evaluated. RESULTS: The chance of detecting incompatibilities by randomly crossmatching 2 cats was 3.9%, which resulted in at least 7% of type A cats having NOAb. Blood typing and agreement analyses performed with 7 newly detected NOAb allowed the identification of 5 presumably distinct FEA. Feline erythrocyte antigens 1 and 5 were most frequent with prevalence of 84% and 96%, respectively. Only FEA 1‐negative status was associated with a higher risk of presenting NOAb; with 16.7% of 42 FEA 1‐negative cats having NOAb compared to 5.1% of 216 FEA 1‐positive cats. CONCLUSIONS AND CLINICAL IMPORTANCE: This study represents a first step of FEA identification outside the AB system. Because of its prevalence and association with NOAb, FEA 1 might correspond to the Mik antigen. John Wiley & Sons, Inc. 2020-12-18 2021 /pmc/articles/PMC7848337/ /pubmed/33336860 http://dx.doi.org/10.1111/jvim.16010 Text en © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Binvel, Marie
Arsenault, Julie
Depré, Boris
Blais, Marie‐Claude
Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title_full Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title_fullStr Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title_full_unstemmed Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title_short Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
title_sort identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848337/
https://www.ncbi.nlm.nih.gov/pubmed/33336860
http://dx.doi.org/10.1111/jvim.16010
work_keys_str_mv AT binvelmarie identificationof5novelfelineerythrocyteantigensbasedonthepresenceofnaturallyoccurringalloantibodies
AT arsenaultjulie identificationof5novelfelineerythrocyteantigensbasedonthepresenceofnaturallyoccurringalloantibodies
AT depreboris identificationof5novelfelineerythrocyteantigensbasedonthepresenceofnaturallyoccurringalloantibodies
AT blaismarieclaude identificationof5novelfelineerythrocyteantigensbasedonthepresenceofnaturallyoccurringalloantibodies