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In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging
BACKGROUND: Degenerative myelopathy (DM) in dogs is a progressive neurodegenerative condition that causes white matter spinal cord lesions. These lesions are undetectable on standard magnetic resonance imaging (MRI), limiting diagnosis and monitoring of the disease. Spinal cord lesions cause disrupt...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848345/ https://www.ncbi.nlm.nih.gov/pubmed/33350517 http://dx.doi.org/10.1111/jvim.16014 |
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author | Johnson, Philippa J. Miller, Andrew D. Cheetham, Jonathan Demeter, Elena A. Luh, Wen‐Ming Loftus, John P. Stephan, Sarah L. Dewey, Curtis W. Barry, Erica F. |
author_facet | Johnson, Philippa J. Miller, Andrew D. Cheetham, Jonathan Demeter, Elena A. Luh, Wen‐Ming Loftus, John P. Stephan, Sarah L. Dewey, Curtis W. Barry, Erica F. |
author_sort | Johnson, Philippa J. |
collection | PubMed |
description | BACKGROUND: Degenerative myelopathy (DM) in dogs is a progressive neurodegenerative condition that causes white matter spinal cord lesions. These lesions are undetectable on standard magnetic resonance imaging (MRI), limiting diagnosis and monitoring of the disease. Spinal cord lesions cause disruption to the structural integrity of the axons causing water diffusion to become more random and less anisotropic. These changes are detectable by the technique of diffusion tensor imaging (DTI) which is highly sensitive to diffusion alterations secondary to white matter lesion development. OBJECTIVE: Perform spinal DTI on cohorts of dogs with and without DM to identify if lesions caused by DM will cause a detectable alteration in spinal cord diffusivity that correlates with neurological status. ANIMALS: Thirteen dogs with DM and 13 aged‐matched controls. METHODS: All animals underwent MRI with DTI of the entire spine. Diffusivity parameters fractional anisotropy (FA) and mean diffusivity (MD) were measured at each vertebral level and statistically compared between groups. RESULTS: Dogs with DM had significant decreases in FA within the regions of the spinal cord that had high expected lesion load. Decreases in FA were most significant in dogs with severe forms of the disease and correlated with neurological grade. CONCLUSIONS AND CLINICAL IMPORTANCE: Findings suggest that FA has the potential to be a biomarker for spinal cord lesion development in DM and could play an important role in improving diagnosis and monitoring of this condition. |
format | Online Article Text |
id | pubmed-7848345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78483452021-02-05 In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging Johnson, Philippa J. Miller, Andrew D. Cheetham, Jonathan Demeter, Elena A. Luh, Wen‐Ming Loftus, John P. Stephan, Sarah L. Dewey, Curtis W. Barry, Erica F. J Vet Intern Med SMALL ANIMAL BACKGROUND: Degenerative myelopathy (DM) in dogs is a progressive neurodegenerative condition that causes white matter spinal cord lesions. These lesions are undetectable on standard magnetic resonance imaging (MRI), limiting diagnosis and monitoring of the disease. Spinal cord lesions cause disruption to the structural integrity of the axons causing water diffusion to become more random and less anisotropic. These changes are detectable by the technique of diffusion tensor imaging (DTI) which is highly sensitive to diffusion alterations secondary to white matter lesion development. OBJECTIVE: Perform spinal DTI on cohorts of dogs with and without DM to identify if lesions caused by DM will cause a detectable alteration in spinal cord diffusivity that correlates with neurological status. ANIMALS: Thirteen dogs with DM and 13 aged‐matched controls. METHODS: All animals underwent MRI with DTI of the entire spine. Diffusivity parameters fractional anisotropy (FA) and mean diffusivity (MD) were measured at each vertebral level and statistically compared between groups. RESULTS: Dogs with DM had significant decreases in FA within the regions of the spinal cord that had high expected lesion load. Decreases in FA were most significant in dogs with severe forms of the disease and correlated with neurological grade. CONCLUSIONS AND CLINICAL IMPORTANCE: Findings suggest that FA has the potential to be a biomarker for spinal cord lesion development in DM and could play an important role in improving diagnosis and monitoring of this condition. John Wiley & Sons, Inc. 2020-12-22 2021 /pmc/articles/PMC7848345/ /pubmed/33350517 http://dx.doi.org/10.1111/jvim.16014 Text en © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Johnson, Philippa J. Miller, Andrew D. Cheetham, Jonathan Demeter, Elena A. Luh, Wen‐Ming Loftus, John P. Stephan, Sarah L. Dewey, Curtis W. Barry, Erica F. In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title | In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title_full | In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title_fullStr | In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title_full_unstemmed | In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title_short | In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
title_sort | in vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848345/ https://www.ncbi.nlm.nih.gov/pubmed/33350517 http://dx.doi.org/10.1111/jvim.16014 |
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