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Overexpression of alpha‐1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice

Islet/β cell dysfunction and death caused by autoimmune‐mediated injuries are major features of type 1 diabetes (T1D). Mesenchymal stromal cells (MSCs) have been used for the treatment of T1D in animal models and clinical trials. Based on the anti‐inflammatory effects of alpha‐1 antitrypsin (AAT), w...

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Detalles Bibliográficos
Autores principales:	Song, Lili, Gou, Wenyu, Wang, Jingjing, Wei, Hua, Lee, Jennifer, Strange, Charlie, Wang, Hongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Tissue Engineering and Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848369/ https://www.ncbi.nlm.nih.gov/pubmed/32945622 http://dx.doi.org/10.1002/sctm.20-0122

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