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OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells

OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly,...

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Autores principales: Li, Juan, Liu, Chunyan, Li, Dawei, Wan, Meng, Zhang, Hong, Zheng, Xiaoxia, Jie, Xuemei, Zhang, Pengju, Li, Jingjing, Hou, Hongchun, Sun, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848444/
https://www.ncbi.nlm.nih.gov/pubmed/30764901
http://dx.doi.org/10.3727/096504018X15399955297355
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author Li, Juan
Liu, Chunyan
Li, Dawei
Wan, Meng
Zhang, Hong
Zheng, Xiaoxia
Jie, Xuemei
Zhang, Pengju
Li, Jingjing
Hou, Hongchun
Sun, Qing
author_facet Li, Juan
Liu, Chunyan
Li, Dawei
Wan, Meng
Zhang, Hong
Zheng, Xiaoxia
Jie, Xuemei
Zhang, Pengju
Li, Jingjing
Hou, Hongchun
Sun, Qing
author_sort Li, Juan
collection PubMed
description OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened by phosphatidic acid (PA)-induced mTOR signal activation, which implicates the potential role of the mTOR pathway in OLFM4-related cervical metastasis. In conclusion, our results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway.
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spelling pubmed-78484442021-02-16 OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells Li, Juan Liu, Chunyan Li, Dawei Wan, Meng Zhang, Hong Zheng, Xiaoxia Jie, Xuemei Zhang, Pengju Li, Jingjing Hou, Hongchun Sun, Qing Oncol Res Article OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened by phosphatidic acid (PA)-induced mTOR signal activation, which implicates the potential role of the mTOR pathway in OLFM4-related cervical metastasis. In conclusion, our results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway. Cognizant Communication Corporation 2019-07-12 /pmc/articles/PMC7848444/ /pubmed/30764901 http://dx.doi.org/10.3727/096504018X15399955297355 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Li, Juan
Liu, Chunyan
Li, Dawei
Wan, Meng
Zhang, Hong
Zheng, Xiaoxia
Jie, Xuemei
Zhang, Pengju
Li, Jingjing
Hou, Hongchun
Sun, Qing
OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title_full OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title_fullStr OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title_full_unstemmed OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title_short OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells
title_sort olfm4 inhibits epithelial–mesenchymal transition and metastatic potential of cervical cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848444/
https://www.ncbi.nlm.nih.gov/pubmed/30764901
http://dx.doi.org/10.3727/096504018X15399955297355
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