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H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7

The long noncoding RNA (lncRNA) H19 has been described to participate in the metastasis of various tumors. Nevertheless, whether H19 promotes or impedes tongue squamous cell carcinoma (TSCC) cell migration and invasion remains controversial. Here we found that the expression of H19 was elevated in T...

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Autores principales: Kou, Ni, Liu, Sha, Li, Xiaojie, Li, Wuwei, Zhong, Weijian, Gui, Lin, Chai, Songling, Ren, Xiang, Na, Risu, Zeng, Tao, Liu, Huiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848458/
https://www.ncbi.nlm.nih.gov/pubmed/29523225
http://dx.doi.org/10.3727/096504018X15202945197589
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author Kou, Ni
Liu, Sha
Li, Xiaojie
Li, Wuwei
Zhong, Weijian
Gui, Lin
Chai, Songling
Ren, Xiang
Na, Risu
Zeng, Tao
Liu, Huiying
author_facet Kou, Ni
Liu, Sha
Li, Xiaojie
Li, Wuwei
Zhong, Weijian
Gui, Lin
Chai, Songling
Ren, Xiang
Na, Risu
Zeng, Tao
Liu, Huiying
author_sort Kou, Ni
collection PubMed
description The long noncoding RNA (lncRNA) H19 has been described to participate in the metastasis of various tumors. Nevertheless, whether H19 promotes or impedes tongue squamous cell carcinoma (TSCC) cell migration and invasion remains controversial. Here we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with unmetastasized tumors. Consistently, TSCC cells express higher levels of H19 than human squamous cells. Subsequently, depletion of H19 impaired the migration and invasion abilities of TSCC cells. Mechanistically, we demonstrated that H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a, leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2, which is enriched in TSCC tissues and cell lines. Intriguingly, inhibition of let-7a significantly rescued the short hairpin H19 (shH19)-induced decrease in TSCC migration and invasion. These findings revealed that the H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion, which may provide a new therapeutic target for TSCC.
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spelling pubmed-78484582021-02-16 H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7 Kou, Ni Liu, Sha Li, Xiaojie Li, Wuwei Zhong, Weijian Gui, Lin Chai, Songling Ren, Xiang Na, Risu Zeng, Tao Liu, Huiying Oncol Res Article The long noncoding RNA (lncRNA) H19 has been described to participate in the metastasis of various tumors. Nevertheless, whether H19 promotes or impedes tongue squamous cell carcinoma (TSCC) cell migration and invasion remains controversial. Here we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with unmetastasized tumors. Consistently, TSCC cells express higher levels of H19 than human squamous cells. Subsequently, depletion of H19 impaired the migration and invasion abilities of TSCC cells. Mechanistically, we demonstrated that H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a, leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2, which is enriched in TSCC tissues and cell lines. Intriguingly, inhibition of let-7a significantly rescued the short hairpin H19 (shH19)-induced decrease in TSCC migration and invasion. These findings revealed that the H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion, which may provide a new therapeutic target for TSCC. Cognizant Communication Corporation 2019-02-05 /pmc/articles/PMC7848458/ /pubmed/29523225 http://dx.doi.org/10.3727/096504018X15202945197589 Text en Copyright © 2019 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Kou, Ni
Liu, Sha
Li, Xiaojie
Li, Wuwei
Zhong, Weijian
Gui, Lin
Chai, Songling
Ren, Xiang
Na, Risu
Zeng, Tao
Liu, Huiying
H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title_full H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title_fullStr H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title_full_unstemmed H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title_short H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7
title_sort h19 facilitates tongue squamous cell carcinoma migration and invasion via sponging mir-let-7
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848458/
https://www.ncbi.nlm.nih.gov/pubmed/29523225
http://dx.doi.org/10.3727/096504018X15202945197589
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