Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer disease (AD). We examined if isoform-selective partial redu...

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Detalles Bibliográficos
Autores principales: Amaral, Ana Claudia, Perez-Nievas, Beatriz G., Siao Tick Chong, Michael, Gonzalez-Martinez, Alicia, Argente-Escrig, Herminia, Rubio-Guerra, Sara, Commins, Caitlin, Muftu, Serra, Eftekharzadeh, Bahareh, Hudry, Eloise, Fan, Zhanyun, Ramanan, Prianca, Takeda, Shuko, Frosch, Matthew P., Wegmann, Susanne, Gomez-Isla, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848608/
https://www.ncbi.nlm.nih.gov/pubmed/33554064
http://dx.doi.org/10.1016/j.isci.2021.102058

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