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Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers
BACKGROUND: MR diffusion weighted imaging (DWI) may provide important information regarding the pathophysiology of parenchymal abdominal organs. The purpose of our study was to investigate the stability of imaging biomarkers of diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848648/ https://www.ncbi.nlm.nih.gov/pubmed/33553749 http://dx.doi.org/10.1016/j.heliyon.2021.e06072 |
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author | Kemėšienė, Jūratė Rühle, Alexander Gomolka, Ryszard Wurnig, Moritz C. Rossi, Cristina Boss, Andreas |
author_facet | Kemėšienė, Jūratė Rühle, Alexander Gomolka, Ryszard Wurnig, Moritz C. Rossi, Cristina Boss, Andreas |
author_sort | Kemėšienė, Jūratė |
collection | PubMed |
description | BACKGROUND: MR diffusion weighted imaging (DWI) may provide important information regarding the pathophysiology of parenchymal abdominal organs. The purpose of our study was to investigate the stability of imaging biomarkers of diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in abdominal parenchymal organs regarding two body hydration states. METHODS: Ten healthy volunteers twice underwent DWI of abdominal organs using a double-refocused spin-echo echo-planar imaging sequences with 11 different b-values (ranging from 0 to 1,500 s/mm(2)): after 4 h of fluid deprivation; 45 min following 1000 ml of water intake. Four different diffusion models were evaluated and compared: standard DWI, DKI with mono-exponential fitting, multistep algorithm with variable b-value threshold for IVIM, combined IVIM-Kurtosis; in four abdominal organs: kidneys, liver, spleen and psoas muscle. RESULTS: Diffusion parameters from all four models remained similar for the renal parenchyma before and after the water challenge. Significant differences were found for the liver, spleen, and psoas muscle. The largest effects were seen for: the liver parenchyma after the water challenge by means of IVIM model's true diffusion (p < 0.02); the spleen, for IVIM's perfusion fraction (p < 0.03), the psoas muscle for the ADC value (p < 0.02). CONCLUSIONS: Herein, we showed that diffusion parameters of the kidney remain remarkably stable regarding the hydration status. This may be attributed to the kidney-specific compensatory mechanisms. For the liver, spleen and psoas muscle the diffusion parameters were sensitive to changes of the hydration. This phenomenon needs to be considered when evaluating diffusion data of these organs. |
format | Online Article Text |
id | pubmed-7848648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-78486482021-02-04 Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers Kemėšienė, Jūratė Rühle, Alexander Gomolka, Ryszard Wurnig, Moritz C. Rossi, Cristina Boss, Andreas Heliyon Research Article BACKGROUND: MR diffusion weighted imaging (DWI) may provide important information regarding the pathophysiology of parenchymal abdominal organs. The purpose of our study was to investigate the stability of imaging biomarkers of diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in abdominal parenchymal organs regarding two body hydration states. METHODS: Ten healthy volunteers twice underwent DWI of abdominal organs using a double-refocused spin-echo echo-planar imaging sequences with 11 different b-values (ranging from 0 to 1,500 s/mm(2)): after 4 h of fluid deprivation; 45 min following 1000 ml of water intake. Four different diffusion models were evaluated and compared: standard DWI, DKI with mono-exponential fitting, multistep algorithm with variable b-value threshold for IVIM, combined IVIM-Kurtosis; in four abdominal organs: kidneys, liver, spleen and psoas muscle. RESULTS: Diffusion parameters from all four models remained similar for the renal parenchyma before and after the water challenge. Significant differences were found for the liver, spleen, and psoas muscle. The largest effects were seen for: the liver parenchyma after the water challenge by means of IVIM model's true diffusion (p < 0.02); the spleen, for IVIM's perfusion fraction (p < 0.03), the psoas muscle for the ADC value (p < 0.02). CONCLUSIONS: Herein, we showed that diffusion parameters of the kidney remain remarkably stable regarding the hydration status. This may be attributed to the kidney-specific compensatory mechanisms. For the liver, spleen and psoas muscle the diffusion parameters were sensitive to changes of the hydration. This phenomenon needs to be considered when evaluating diffusion data of these organs. Elsevier 2021-01-28 /pmc/articles/PMC7848648/ /pubmed/33553749 http://dx.doi.org/10.1016/j.heliyon.2021.e06072 Text en © 2021 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Kemėšienė, Jūratė Rühle, Alexander Gomolka, Ryszard Wurnig, Moritz C. Rossi, Cristina Boss, Andreas Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title | Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title_full | Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title_fullStr | Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title_full_unstemmed | Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title_short | Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
title_sort | advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848648/ https://www.ncbi.nlm.nih.gov/pubmed/33553749 http://dx.doi.org/10.1016/j.heliyon.2021.e06072 |
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