PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

DNA damage repair genes are modifiers of disease onset in Huntington’s disease (HD), but how this process intersects with associated disease pathways remains unclear. Here we evaluated the mechanistic contributions of protein inhibitor of activated STAT-1 (PIAS1) in HD mice and HD patient-derived in...

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Detalles Bibliográficos
Autores principales: Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848703/
https://www.ncbi.nlm.nih.gov/pubmed/33468657
http://dx.doi.org/10.1073/pnas.2021836118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848703/
https://www.ncbi.nlm.nih.gov/pubmed/33468657
http://dx.doi.org/10.1073/pnas.2021836118

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