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Automated generation of gene-edited CAR T cells at clinical scale

The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contamination. Here, we present an automated T cell engineerin...

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Detalles Bibliográficos
Autores principales:	Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848723/ https://www.ncbi.nlm.nih.gov/pubmed/33575430 http://dx.doi.org/10.1016/j.omtm.2020.12.008

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