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Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic

INTRODUCTION: Squamous carcinoma is a very rare breast cancer resulting from a differentiated squamous metaplasia. Its diagnosis is late due to the absence of specific clinical and radiological features. PRESENTATION OF CASE: The authors present the case of a 39-year-old patient with the clinical on...

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Autores principales: Tomasicchio, G., Rizzi, A., Stucci, L.S., Moschetta, M., Giliberti, G., Punzo, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848728/
https://www.ncbi.nlm.nih.gov/pubmed/33517214
http://dx.doi.org/10.1016/j.ijscr.2021.01.079
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author Tomasicchio, G.
Rizzi, A.
Stucci, L.S.
Moschetta, M.
Giliberti, G.
Punzo, C.
author_facet Tomasicchio, G.
Rizzi, A.
Stucci, L.S.
Moschetta, M.
Giliberti, G.
Punzo, C.
author_sort Tomasicchio, G.
collection PubMed
description INTRODUCTION: Squamous carcinoma is a very rare breast cancer resulting from a differentiated squamous metaplasia. Its diagnosis is late due to the absence of specific clinical and radiological features. PRESENTATION OF CASE: The authors present the case of a 39-year-old patient with the clinical onset of an inflammatory cyst diagnosed with mammography and cytological examination. After segmentectomy, on histological examination was defined as: “squamous keratinizing aspect”. In light of this report she was subjected to quadrantectomy with lymphadenectomy. She did not undergo radiotherapy treatment, which was delayed due to the ongoing pandemic. After a few months developed a local recurrence and underwent a mastectomy with multidisciplinary treatment. DISCUSSION: Squamously-differentiated metaplastic carcinoma of the breast is one of the rarest forms of breast cancer. Its etiopathogenesis is still unclear but some authors suggest that it originates from a squamous metaplasia deriving from the epithelium of cysts. This is a very aggressive and fast-growing tumour especially in young women, in fact the patient had a recurrence after a few months. She came to our attention 6 months after the initial surgery with a relapse at a local-regional level for which she was subjected to radical treatment and with a metastatic spread for which she was given the first-line chemotherapy treatment. CONCLUSION: There are no well-defined guidelines for the treatment of this rare form of cancer. The case illustrates how the rapid aggressiveness of the disease requires adequate and immediate multidisciplinary treatment from the very beginning.
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spelling pubmed-78487282021-02-04 Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic Tomasicchio, G. Rizzi, A. Stucci, L.S. Moschetta, M. Giliberti, G. Punzo, C. Int J Surg Case Rep Case Report INTRODUCTION: Squamous carcinoma is a very rare breast cancer resulting from a differentiated squamous metaplasia. Its diagnosis is late due to the absence of specific clinical and radiological features. PRESENTATION OF CASE: The authors present the case of a 39-year-old patient with the clinical onset of an inflammatory cyst diagnosed with mammography and cytological examination. After segmentectomy, on histological examination was defined as: “squamous keratinizing aspect”. In light of this report she was subjected to quadrantectomy with lymphadenectomy. She did not undergo radiotherapy treatment, which was delayed due to the ongoing pandemic. After a few months developed a local recurrence and underwent a mastectomy with multidisciplinary treatment. DISCUSSION: Squamously-differentiated metaplastic carcinoma of the breast is one of the rarest forms of breast cancer. Its etiopathogenesis is still unclear but some authors suggest that it originates from a squamous metaplasia deriving from the epithelium of cysts. This is a very aggressive and fast-growing tumour especially in young women, in fact the patient had a recurrence after a few months. She came to our attention 6 months after the initial surgery with a relapse at a local-regional level for which she was subjected to radical treatment and with a metastatic spread for which she was given the first-line chemotherapy treatment. CONCLUSION: There are no well-defined guidelines for the treatment of this rare form of cancer. The case illustrates how the rapid aggressiveness of the disease requires adequate and immediate multidisciplinary treatment from the very beginning. Elsevier 2021-01-22 /pmc/articles/PMC7848728/ /pubmed/33517214 http://dx.doi.org/10.1016/j.ijscr.2021.01.079 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tomasicchio, G.
Rizzi, A.
Stucci, L.S.
Moschetta, M.
Giliberti, G.
Punzo, C.
Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title_full Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title_fullStr Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title_full_unstemmed Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title_short Metaplastic squamous cell breast cancer: A case report and treatment strategy during covid-19 pandemic
title_sort metaplastic squamous cell breast cancer: a case report and treatment strategy during covid-19 pandemic
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848728/
https://www.ncbi.nlm.nih.gov/pubmed/33517214
http://dx.doi.org/10.1016/j.ijscr.2021.01.079
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