Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF

In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates N(δ) and N(ω)′ of N(ω)-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure vis...

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Detalles Bibliográficos
Autores principales: McBride, Molly J., Pope, Sarah R., Hu, Kai, Okafor, C. Denise, Balskus, Emily P., Bollinger, J. Martin, Boal, Amie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848743/
https://www.ncbi.nlm.nih.gov/pubmed/33468680
http://dx.doi.org/10.1073/pnas.2015931118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848743/
https://www.ncbi.nlm.nih.gov/pubmed/33468680
http://dx.doi.org/10.1073/pnas.2015931118

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