Cargando…
Racial differences in the distribution of bladder cancer metastases: a population-based analysis
INTRODUCTION: Bladder cancer is the second most common genitourinary malignancy in the United States. The incidence of bladder cancer rises with age, and it is two times more common in Caucasians than in African-Americans (23.1 vs. 12.6 cases/100,000 persons). We aimed to investigate the racial and...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848828/ https://www.ncbi.nlm.nih.gov/pubmed/33552564 http://dx.doi.org/10.5173/ceju.2020.0269 |
_version_ | 1783645209310003200 |
---|---|
author | Rosiello, Giuseppe Palumbo, Carlotta Deuker, Marina Stolzenbach, Lara Franziska Martin, Thomas Tian, Zhe Gallina, Andrea Montorsi, Francesco Black, Peter Kassouf, Wassim Shariat, Shahrokh F. Saad, Fred Briganti, Alberto Karakiewicz, Pierre I. |
author_facet | Rosiello, Giuseppe Palumbo, Carlotta Deuker, Marina Stolzenbach, Lara Franziska Martin, Thomas Tian, Zhe Gallina, Andrea Montorsi, Francesco Black, Peter Kassouf, Wassim Shariat, Shahrokh F. Saad, Fred Briganti, Alberto Karakiewicz, Pierre I. |
author_sort | Rosiello, Giuseppe |
collection | PubMed |
description | INTRODUCTION: Bladder cancer is the second most common genitourinary malignancy in the United States. The incidence of bladder cancer rises with age, and it is two times more common in Caucasians than in African-Americans (23.1 vs. 12.6 cases/100,000 persons). We aimed to investigate the racial and age-related differences in the distribution of metastasis in a large, contemporary cohort of metastatic bladder cancer patients. MATERIAL AND METHODS: Within the National Inpatient Sample database (2008–2015) we identified 5,767 patients with metastatic bladder cancer. Trend test, Chi-square test and multivariable logistic regression models were used to evaluate the relationship between ethnicity, age, and site of metastasis. RESULTS: Of 5,767 patients with metastatic bladder cancer, 598 (10.4%) were African-American. Lung was the most common metastatic site in African-Americans (28.6%) vs. bone in Caucasians (21.7%). Overall, African-Americans showed higher rates of lung (+10.2%), liver (+7.5%) and bone (+5.2%) metastases, compared to Caucasians (all p <0.01). Brain metastases were rare in both ethnicities (3.3 vs. 2.4%; p = 0.2). Rates of exclusive bone, lung or liver metastases increased with age, but were higher in African-Americans, regardless of age strata. In the multivariable logistic regression models, African-American ethnicity independently predicted higher risk of lung (Odds ratio: 1.69), liver (odds ratio: 1.50) and bone (odds ratio: 1.27) metastases, relative to Caucasians. Moreover, a dose-response effect was found after combining the three main risk factors for developing bone metastases, namely African-American ethnicity, younger age and male gender. CONCLUSIONS: Racial differences exist in the distribution of metastatic bladder cancer metastasis. Moreover, based on higher risk of bone metastases in African-American patients, bone imaging may be warranted in this patient population, especially in the presence of other risk factors for bone metastases, namely male gender or younger age. |
format | Online Article Text |
id | pubmed-7848828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-78488282021-02-04 Racial differences in the distribution of bladder cancer metastases: a population-based analysis Rosiello, Giuseppe Palumbo, Carlotta Deuker, Marina Stolzenbach, Lara Franziska Martin, Thomas Tian, Zhe Gallina, Andrea Montorsi, Francesco Black, Peter Kassouf, Wassim Shariat, Shahrokh F. Saad, Fred Briganti, Alberto Karakiewicz, Pierre I. Cent European J Urol Original Paper INTRODUCTION: Bladder cancer is the second most common genitourinary malignancy in the United States. The incidence of bladder cancer rises with age, and it is two times more common in Caucasians than in African-Americans (23.1 vs. 12.6 cases/100,000 persons). We aimed to investigate the racial and age-related differences in the distribution of metastasis in a large, contemporary cohort of metastatic bladder cancer patients. MATERIAL AND METHODS: Within the National Inpatient Sample database (2008–2015) we identified 5,767 patients with metastatic bladder cancer. Trend test, Chi-square test and multivariable logistic regression models were used to evaluate the relationship between ethnicity, age, and site of metastasis. RESULTS: Of 5,767 patients with metastatic bladder cancer, 598 (10.4%) were African-American. Lung was the most common metastatic site in African-Americans (28.6%) vs. bone in Caucasians (21.7%). Overall, African-Americans showed higher rates of lung (+10.2%), liver (+7.5%) and bone (+5.2%) metastases, compared to Caucasians (all p <0.01). Brain metastases were rare in both ethnicities (3.3 vs. 2.4%; p = 0.2). Rates of exclusive bone, lung or liver metastases increased with age, but were higher in African-Americans, regardless of age strata. In the multivariable logistic regression models, African-American ethnicity independently predicted higher risk of lung (Odds ratio: 1.69), liver (odds ratio: 1.50) and bone (odds ratio: 1.27) metastases, relative to Caucasians. Moreover, a dose-response effect was found after combining the three main risk factors for developing bone metastases, namely African-American ethnicity, younger age and male gender. CONCLUSIONS: Racial differences exist in the distribution of metastatic bladder cancer metastasis. Moreover, based on higher risk of bone metastases in African-American patients, bone imaging may be warranted in this patient population, especially in the presence of other risk factors for bone metastases, namely male gender or younger age. Polish Urological Association 2020-10-31 2020 /pmc/articles/PMC7848828/ /pubmed/33552564 http://dx.doi.org/10.5173/ceju.2020.0269 Text en Copyright by Polish Urological Association http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Rosiello, Giuseppe Palumbo, Carlotta Deuker, Marina Stolzenbach, Lara Franziska Martin, Thomas Tian, Zhe Gallina, Andrea Montorsi, Francesco Black, Peter Kassouf, Wassim Shariat, Shahrokh F. Saad, Fred Briganti, Alberto Karakiewicz, Pierre I. Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title | Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title_full | Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title_fullStr | Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title_full_unstemmed | Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title_short | Racial differences in the distribution of bladder cancer metastases: a population-based analysis |
title_sort | racial differences in the distribution of bladder cancer metastases: a population-based analysis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848828/ https://www.ncbi.nlm.nih.gov/pubmed/33552564 http://dx.doi.org/10.5173/ceju.2020.0269 |
work_keys_str_mv | AT rosiellogiuseppe racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT palumbocarlotta racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT deukermarina racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT stolzenbachlarafranziska racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT martinthomas racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT tianzhe racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT gallinaandrea racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT montorsifrancesco racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT blackpeter racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT kassoufwassim racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT shariatshahrokhf racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT saadfred racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT brigantialberto racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis AT karakiewiczpierrei racialdifferencesinthedistributionofbladdercancermetastasesapopulationbasedanalysis |