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BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS

Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due t...

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Autores principales: Gaud, Caroline, C. Sousa, Bebiana, Nguyen, An, Fedorova, Maria, Ni, Zhixu, O’Donnell, Valerie B., Wakelam, Michael J.O., Andrews, Simon, Lopez-Clavijo, Andrea F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848852/
https://www.ncbi.nlm.nih.gov/pubmed/33564392
http://dx.doi.org/10.12688/f1000research.28022.2
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author Gaud, Caroline
C. Sousa, Bebiana
Nguyen, An
Fedorova, Maria
Ni, Zhixu
O’Donnell, Valerie B.
Wakelam, Michael J.O.
Andrews, Simon
Lopez-Clavijo, Andrea F.
author_facet Gaud, Caroline
C. Sousa, Bebiana
Nguyen, An
Fedorova, Maria
Ni, Zhixu
O’Donnell, Valerie B.
Wakelam, Michael J.O.
Andrews, Simon
Lopez-Clavijo, Andrea F.
author_sort Gaud, Caroline
collection PubMed
description Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways.  As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging.  BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways.  BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.
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spelling pubmed-78488522021-02-08 BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS Gaud, Caroline C. Sousa, Bebiana Nguyen, An Fedorova, Maria Ni, Zhixu O’Donnell, Valerie B. Wakelam, Michael J.O. Andrews, Simon Lopez-Clavijo, Andrea F. F1000Res Software Tool Article Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways.  As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging.  BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways.  BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues. F1000 Research Limited 2021-06-09 /pmc/articles/PMC7848852/ /pubmed/33564392 http://dx.doi.org/10.12688/f1000research.28022.2 Text en Copyright: © 2021 Gaud C et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software Tool Article
Gaud, Caroline
C. Sousa, Bebiana
Nguyen, An
Fedorova, Maria
Ni, Zhixu
O’Donnell, Valerie B.
Wakelam, Michael J.O.
Andrews, Simon
Lopez-Clavijo, Andrea F.
BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title_full BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title_fullStr BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title_full_unstemmed BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title_short BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS
title_sort biopan: a web-based tool to explore mammalian lipidome metabolic pathways on lipid maps
topic Software Tool Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848852/
https://www.ncbi.nlm.nih.gov/pubmed/33564392
http://dx.doi.org/10.12688/f1000research.28022.2
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