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Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target

The TMPRSS2–ERG gene fusion and subsequent overexpression of the ERG transcription factor occurs in ∼50% of prostate tumors, making it the most common abnormality of the prostate cancer genome. While ERG has been shown to drive tumor progression and cancer-related phenotypes, as a transcription fact...

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Detalles Bibliográficos
Autores principales:	Greulich, Benjamin M, Plotnik, Joshua P, Jerde, Travis J, Hollenhorst, Peter C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848947/ https://www.ncbi.nlm.nih.gov/pubmed/33554122 http://dx.doi.org/10.1093/narcan/zcaa046

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