The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

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In B lymphocytes, the uracil N-glycosylase (UNG) excises genomic uracils made by activation-induced deaminase (AID), thus underpinning antibody gene diversification and oncogenic chromosomal translocations, but also initiating faithful DNA repair. Ung(−/−) mice develop B-cell lymphoma (BCL). However...

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Detalles Bibliográficos
Autores principales: Safavi, Shiva, Larouche, Ariane, Zahn, Astrid, Patenaude, Anne-Marie, Domanska, Diana, Dionne, Kiersten, Rognes, Torbjørn, Dingler, Felix, Kang, Seong-Kwi, Liu, Yan, Johnson, Nathalie, Hébert, Josée, Verdun, Ramiro E, Rada, Cristina A, Vega, Francisco, Nilsen, Hilde, Di Noia, Javier M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848951/
https://www.ncbi.nlm.nih.gov/pubmed/33554121
http://dx.doi.org/10.1093/narcan/zcaa019
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