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Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

β-Lactam antibiotics are presently the most important treatments for infections by pathogenic Escherichia coli, but their use is increasingly compromised by β-lactamases, including the chromosomally encoded class C AmpC serine-β-lactamases (SBLs). The diazabicyclooctane (DBO) avibactam is a potent A...

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Detalles Bibliográficos
Autores principales:	Lang, Pauline A., Leissing, Thomas M., Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849013/ https://www.ncbi.nlm.nih.gov/pubmed/33199391 http://dx.doi.org/10.1128/AAC.02073-20

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