Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

Remdesivir (RDV, GS-5734), the first FDA-approved antiviral for the treatment of COVID-19, is a single diastereomer monophosphoramidate prodrug of an adenosine analogue. It is intracellularly metabolized into the active triphosphate form, which in turn acts as a potent and selective inhibitor of mul...

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Detalles Bibliográficos
Autores principales: Xu, Yili, Barauskas, Ona, Kim, Cynthia, Babusis, Darius, Murakami, Eisuke, Kornyeyev, Dmytro, Lee, Gary, Stepan, George, Perron, Michel, Bannister, Roy, Schultz, Brian E., Sakowicz, Roman, Porter, Danielle, Cihlar, Tomas, Feng, Joy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849018/
https://www.ncbi.nlm.nih.gov/pubmed/33229429
http://dx.doi.org/10.1128/AAC.02237-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849018/
https://www.ncbi.nlm.nih.gov/pubmed/33229429
http://dx.doi.org/10.1128/AAC.02237-20

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