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端粒与端粒酶研究在肺癌中的临床应用前景与挑战
Lung cancer is one of the malignant tumors with high incidence rate and high mortality worldwide. Telomere and telomerase are closely related to the occurrence and development of lung cancer. Although telomerase may not be the direct cause of carcinogenesis, it plays a key role in maintaining telome...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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中国肺癌杂志编辑部
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849035/ https://www.ncbi.nlm.nih.gov/pubmed/33478187 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.45 |
_version_ | 1783645236560396288 |
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collection | PubMed |
description | Lung cancer is one of the malignant tumors with high incidence rate and high mortality worldwide. Telomere and telomerase are closely related to the occurrence and development of lung cancer. Although telomerase may not be the direct cause of carcinogenesis, it plays a key role in maintaining telomere length and tumor growth. The length of most tumors, including lung cancer, is shortened. The change of telomere length is related to the risk of lung cancer, and may become the therapeutic target and predictive index. Target drugs for telomere and telomerase signaling pathway are constantly being explored, and drugs represented by telomerase inhibitors are expected to be used in clinical treatment of lung cancer in the future. However, the research on telomere and telomerase is far from enough. The bypass mechanism of telomere length maintenance may be the direction of further research. |
format | Online Article Text |
id | pubmed-7849035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-78490352021-02-04 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 Zhongguo Fei Ai Za Zhi 综述 Lung cancer is one of the malignant tumors with high incidence rate and high mortality worldwide. Telomere and telomerase are closely related to the occurrence and development of lung cancer. Although telomerase may not be the direct cause of carcinogenesis, it plays a key role in maintaining telomere length and tumor growth. The length of most tumors, including lung cancer, is shortened. The change of telomere length is related to the risk of lung cancer, and may become the therapeutic target and predictive index. Target drugs for telomere and telomerase signaling pathway are constantly being explored, and drugs represented by telomerase inhibitors are expected to be used in clinical treatment of lung cancer in the future. However, the research on telomere and telomerase is far from enough. The bypass mechanism of telomere length maintenance may be the direction of further research. 中国肺癌杂志编辑部 2021-01-20 /pmc/articles/PMC7849035/ /pubmed/33478187 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.45 Text en 版权所有©《中国肺癌杂志》编辑部2021 This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/. |
spellingShingle | 综述 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title_full | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title_fullStr | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title_full_unstemmed | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title_short | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
title_sort | 端粒与端粒酶研究在肺癌中的临床应用前景与挑战 |
topic | 综述 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849035/ https://www.ncbi.nlm.nih.gov/pubmed/33478187 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.45 |
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