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Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug

At low temperatures, protein degradation by the AAA+ HslUV protease is very slow. New crystal structures reveal that residues in the intermediate domain of the HslU(6) unfoldase can plug its axial channel, blocking productive substrate binding and subsequent unfolding, translocation, and degradation...

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Detalles Bibliográficos
Autores principales:	Baytshtok, Vladimir, Fei, Xue, Shih, Tsai-Ting, Grant, Robert A., Santos, Justin C., Baker, Tania A., Sauer, Robert T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849044/ https://www.ncbi.nlm.nih.gov/pubmed/33472065 http://dx.doi.org/10.1016/j.celrep.2020.108639

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