A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. METHODS: We complemented a new conventional PC GWAS...

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Detalles Bibliográficos
Autores principales: López de Maturana, Evangelina, Rodríguez, Juan Antonio, Alonso, Lola, Lao, Oscar, Molina-Montes, Esther, Martín-Antoniano, Isabel Adoración, Gómez-Rubio, Paulina, Lawlor, Rita, Carrato, Alfredo, Hidalgo, Manuel, Iglesias, Mar, Molero, Xavier, Löhr, Matthias, Michalski, Christopher, Perea, José, O’Rorke, Michael, Barberà, Victor Manuel, Tardón, Adonina, Farré, Antoni, Muñoz-Bellvís, Luís, Crnogorac-Jurcevic, Tanja, Domínguez-Muñoz, Enrique, Gress, Thomas, Greenhalf, William, Sharp, Linda, Arnes, Luís, Cecchini, Lluís, Balsells, Joaquim, Costello, Eithne, Ilzarbe, Lucas, Kleeff, Jörg, Kong, Bo, Márquez, Mirari, Mora, Josefina, O’Driscoll, Damian, Scarpa, Aldo, Ye, Weimin, Yu, Jingru, García-Closas, Montserrat, Kogevinas, Manolis, Rothman, Nathaniel, Silverman, Debra T, Albanes, Demetrius, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Du, Margaret, Gallinger, Steve, Gaziano, J Michael, Goodman, Phyllis J, Gunter, Marc, LeMarchand, Loic, Li, Donghui, Neale, Rachael E, Peters, Ulrika, Petersen, Gloria M, Risch, Harvey A, Sánchez, Maria José, Shu, Xiao-Ou, Thornquist, Mark D, Visvanathan, Kala, Zheng, Wei, Chanock, Stephen J, Easton, Douglas, Wolpin, Brian M, Stolzenberg-Solomon, Rachael Z, Klein, Alison P, Amundadottir, Laufey T, Marti-Renom, Marc A, Real, Francisco X, Malats, Núria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849104/
https://www.ncbi.nlm.nih.gov/pubmed/33517887
http://dx.doi.org/10.1186/s13073-020-00816-4

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