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Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis
BACKGROUND: Schistosomiasis is a common helminthic infection in the tropics and subtropics, particularly in sub-Saharan African countries including Ethiopia. In these counties, Schistosoma mansoni infection is a significant public health problem due to the risk of reinfection and recurrent disease d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849146/ https://www.ncbi.nlm.nih.gov/pubmed/33522949 http://dx.doi.org/10.1186/s40794-020-00127-x |
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author | Hussen, Siraj Assegu, Demissie Tadesse, Birkneh Tilahun Shimelis, Techalew |
author_facet | Hussen, Siraj Assegu, Demissie Tadesse, Birkneh Tilahun Shimelis, Techalew |
author_sort | Hussen, Siraj |
collection | PubMed |
description | BACKGROUND: Schistosomiasis is a common helminthic infection in the tropics and subtropics, particularly in sub-Saharan African countries including Ethiopia. In these counties, Schistosoma mansoni infection is a significant public health problem due to the risk of reinfection and recurrent disease despite implementing several rounds preventive chemotherapy. This systematic review and meta-analysis aimed at assessing the pooled prevalence of schistosomiasis in Ethiopia. METHODS: The PRISMA guidelines were followed to perform the systematic review and meta-analysis. Published studies from January 1999 to June 2020 were searched in Medline, PubMed, Google Scholar, EMBASE, HINARI, and Cochrane Library using key words including: “prevalence”, “incidence”, “schistosomiasis” “Bilharziasis”, “Bilharzia”, “S. mansoni “, “Ethiopia”. Heterogeneity of included studies was assessed using Cochran’s Q test and I(2) test statistics while publication bias was assessed using Egger’s test. RESULTS: Ninety-four studies were included in the systematic review and meta-analysis. The pooled prevalence of S. mansoni in Ethiopia was 18.0% (95%CI: 14.0–23.0). The southern region of Ethiopia had a higher S. mansoni prevalence of 25.9% (995% CI, 14.9–41.1) than the national prevalence. The burden of S. mansoni infection was also higher than the national average in rural areas and among men with pooled prevalence of 20.2% (95% CI, 13.2–28.5) and 28.5% (95%CI, 22.7,35.1), respectively. The trend analysis showed that the prevalence of S. mansoni infection in Ethiopia decreased over the past 15 years, potentially because of the repeated preventive chemotherapy. CONCLUSION: The review unveiled a moderate prevalence of S. mansoni infection in Ethiopia. Targeted treatment of at-risk population groups ad high burden areas coupled with implementation of integrated vector control strategies are critical to address the burden of Schistosomiasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40794-020-00127-x. |
format | Online Article Text |
id | pubmed-7849146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78491462021-02-03 Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis Hussen, Siraj Assegu, Demissie Tadesse, Birkneh Tilahun Shimelis, Techalew Trop Dis Travel Med Vaccines Review BACKGROUND: Schistosomiasis is a common helminthic infection in the tropics and subtropics, particularly in sub-Saharan African countries including Ethiopia. In these counties, Schistosoma mansoni infection is a significant public health problem due to the risk of reinfection and recurrent disease despite implementing several rounds preventive chemotherapy. This systematic review and meta-analysis aimed at assessing the pooled prevalence of schistosomiasis in Ethiopia. METHODS: The PRISMA guidelines were followed to perform the systematic review and meta-analysis. Published studies from January 1999 to June 2020 were searched in Medline, PubMed, Google Scholar, EMBASE, HINARI, and Cochrane Library using key words including: “prevalence”, “incidence”, “schistosomiasis” “Bilharziasis”, “Bilharzia”, “S. mansoni “, “Ethiopia”. Heterogeneity of included studies was assessed using Cochran’s Q test and I(2) test statistics while publication bias was assessed using Egger’s test. RESULTS: Ninety-four studies were included in the systematic review and meta-analysis. The pooled prevalence of S. mansoni in Ethiopia was 18.0% (95%CI: 14.0–23.0). The southern region of Ethiopia had a higher S. mansoni prevalence of 25.9% (995% CI, 14.9–41.1) than the national prevalence. The burden of S. mansoni infection was also higher than the national average in rural areas and among men with pooled prevalence of 20.2% (95% CI, 13.2–28.5) and 28.5% (95%CI, 22.7,35.1), respectively. The trend analysis showed that the prevalence of S. mansoni infection in Ethiopia decreased over the past 15 years, potentially because of the repeated preventive chemotherapy. CONCLUSION: The review unveiled a moderate prevalence of S. mansoni infection in Ethiopia. Targeted treatment of at-risk population groups ad high burden areas coupled with implementation of integrated vector control strategies are critical to address the burden of Schistosomiasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40794-020-00127-x. BioMed Central 2021-02-01 /pmc/articles/PMC7849146/ /pubmed/33522949 http://dx.doi.org/10.1186/s40794-020-00127-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Hussen, Siraj Assegu, Demissie Tadesse, Birkneh Tilahun Shimelis, Techalew Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title | Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title_full | Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title_fullStr | Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title_full_unstemmed | Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title_short | Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis |
title_sort | prevalence of schistosoma mansoni infection in ethiopia: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849146/ https://www.ncbi.nlm.nih.gov/pubmed/33522949 http://dx.doi.org/10.1186/s40794-020-00127-x |
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