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Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects

Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability hav...

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Autores principales: Zhao, Feng, Wang, Ping, Jiao, Yuanyuan, Zhang, Xiaoxiao, Chen, Daquan, Xu, Haiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849182/
https://www.ncbi.nlm.nih.gov/pubmed/33536906
http://dx.doi.org/10.3389/fphar.2020.579332
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author Zhao, Feng
Wang, Ping
Jiao, Yuanyuan
Zhang, Xiaoxiao
Chen, Daquan
Xu, Haiyu
author_facet Zhao, Feng
Wang, Ping
Jiao, Yuanyuan
Zhang, Xiaoxiao
Chen, Daquan
Xu, Haiyu
author_sort Zhao, Feng
collection PubMed
description Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been severely hampering the clinical applications of HSYA during the treatment of cardiovascular and cerebrovascular disease. Therefore, this present review systematically summarized the materials about HSYA, including acquisition methods, extraction and detection methods, pharmacokinetics, pharmacological effects and molecular mechanism, especially focus on the possible causes and resolutions about the chemical instability and low bioavailability of HSYA, in order to provide relatively comprehensive basic data for the related research of HSYA.
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spelling pubmed-78491822021-02-02 Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects Zhao, Feng Wang, Ping Jiao, Yuanyuan Zhang, Xiaoxiao Chen, Daquan Xu, Haiyu Front Pharmacol Pharmacology Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been severely hampering the clinical applications of HSYA during the treatment of cardiovascular and cerebrovascular disease. Therefore, this present review systematically summarized the materials about HSYA, including acquisition methods, extraction and detection methods, pharmacokinetics, pharmacological effects and molecular mechanism, especially focus on the possible causes and resolutions about the chemical instability and low bioavailability of HSYA, in order to provide relatively comprehensive basic data for the related research of HSYA. Frontiers Media S.A. 2020-12-11 /pmc/articles/PMC7849182/ /pubmed/33536906 http://dx.doi.org/10.3389/fphar.2020.579332 Text en Copyright © 2020 Zhao, Wang, Jiao, Zhang, Chen and Xu. http://Creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhao, Feng
Wang, Ping
Jiao, Yuanyuan
Zhang, Xiaoxiao
Chen, Daquan
Xu, Haiyu
Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title_full Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title_fullStr Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title_full_unstemmed Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title_short Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
title_sort hydroxysafflor yellow a: a systematical review on botanical resources, physicochemical properties, drug delivery system, pharmacokinetics, and pharmacological effects
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849182/
https://www.ncbi.nlm.nih.gov/pubmed/33536906
http://dx.doi.org/10.3389/fphar.2020.579332
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