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A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849205/ https://www.ncbi.nlm.nih.gov/pubmed/33536900 http://dx.doi.org/10.3389/fphar.2020.538137 |
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author | Zhou, Haifeng Li, Junyi Sun, Fei Wang, Faxi Li, Mingyue Dong, Yalan Fan, Heng Hu, Desheng |
author_facet | Zhou, Haifeng Li, Junyi Sun, Fei Wang, Faxi Li, Mingyue Dong, Yalan Fan, Heng Hu, Desheng |
author_sort | Zhou, Haifeng |
collection | PubMed |
description | Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine. |
format | Online Article Text |
id | pubmed-7849205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78492052021-02-02 A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms Zhou, Haifeng Li, Junyi Sun, Fei Wang, Faxi Li, Mingyue Dong, Yalan Fan, Heng Hu, Desheng Front Pharmacol Pharmacology Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7849205/ /pubmed/33536900 http://dx.doi.org/10.3389/fphar.2020.538137 Text en Copyright © 2020 Li, Sun, Zhou, Wang, Dong, Li, Fan and Hu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zhou, Haifeng Li, Junyi Sun, Fei Wang, Faxi Li, Mingyue Dong, Yalan Fan, Heng Hu, Desheng A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title | A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title_full | A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title_fullStr | A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title_full_unstemmed | A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title_short | A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms |
title_sort | review on recent advances in aloperine research: pharmacological activities and underlying biological mechanisms |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849205/ https://www.ncbi.nlm.nih.gov/pubmed/33536900 http://dx.doi.org/10.3389/fphar.2020.538137 |
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