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A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms

Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following th...

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Autores principales: Zhou, Haifeng, Li, Junyi, Sun, Fei, Wang, Faxi, Li, Mingyue, Dong, Yalan, Fan, Heng, Hu, Desheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849205/
https://www.ncbi.nlm.nih.gov/pubmed/33536900
http://dx.doi.org/10.3389/fphar.2020.538137
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author Zhou, Haifeng
Li, Junyi
Sun, Fei
Wang, Faxi
Li, Mingyue
Dong, Yalan
Fan, Heng
Hu, Desheng
author_facet Zhou, Haifeng
Li, Junyi
Sun, Fei
Wang, Faxi
Li, Mingyue
Dong, Yalan
Fan, Heng
Hu, Desheng
author_sort Zhou, Haifeng
collection PubMed
description Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine.
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spelling pubmed-78492052021-02-02 A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms Zhou, Haifeng Li, Junyi Sun, Fei Wang, Faxi Li, Mingyue Dong, Yalan Fan, Heng Hu, Desheng Front Pharmacol Pharmacology Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7849205/ /pubmed/33536900 http://dx.doi.org/10.3389/fphar.2020.538137 Text en Copyright © 2020 Li, Sun, Zhou, Wang, Dong, Li, Fan and Hu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Haifeng
Li, Junyi
Sun, Fei
Wang, Faxi
Li, Mingyue
Dong, Yalan
Fan, Heng
Hu, Desheng
A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title_full A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title_fullStr A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title_full_unstemmed A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title_short A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
title_sort review on recent advances in aloperine research: pharmacological activities and underlying biological mechanisms
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849205/
https://www.ncbi.nlm.nih.gov/pubmed/33536900
http://dx.doi.org/10.3389/fphar.2020.538137
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