Intrinsically disordered protein PID‐2 modulates Z granules and is required for heritable piRNA‐induced silencing in the Caenorhabditis elegans embryo

In Caenorhabditis elegans, the piRNA (21U RNA) pathway is required to establish proper gene regulation and an immortal germline. To achieve this, PRG‐1‐bound 21U RNAs trigger silencing mechanisms mediated by RNA‐dependent RNA polymerase (RdRP)‐synthetized 22G RNAs. This silencing can become PRG‐1‐in...

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Detalles Bibliográficos
Autores principales: Placentino, Maria, de Jesus Domingues, António Miguel, Schreier, Jan, Dietz, Sabrina, Hellmann, Svenja, de Albuquerque, Bruno FM, Butter, Falk, Ketting, René F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849312/
https://www.ncbi.nlm.nih.gov/pubmed/33231880
http://dx.doi.org/10.15252/embj.2020105280

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