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An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia

Reactive oxygen species (ROS) produced by NADPH1 oxidase 1 (NOX1) are thought to drive spermatogonial stem cell (SSC) self-renewal through feed-forward production of ROS by the ROS-BCL6B-NOX1 pathway. Here we report the critical role of oxygen on ROS-induced self-renewal. Cultured SSCs proliferated...

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Detalles Bibliográficos
Autores principales:	Morimoto, Hiroko, Yamamoto, Takuya, Miyazaki, Takehiro, Ogonuki, Narumi, Ogura, Atsuo, Tanaka, Takashi, Kanatsu-Shinohara, Mito, Yabe-Nishimura, Chihiro, Zhang, Hongliang, Pommier, Yves, Trumpp, Andreas, Shinohara, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849365/ https://www.ncbi.nlm.nih.gov/pubmed/33446567 http://dx.doi.org/10.1101/gad.339903.120

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