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The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany

OBJECTIVE: More than 30% of the German population suffers from mild to moderate iodine deficiency causing goiter and other iodine deficiency disorders (IDDs). The economic burden of iodine deficiency is still unclear. We aimed to assess costs for prevention, monitoring and treatment of IDDs in Germa...

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Autores principales: Schaffner, Monika, Rochau, Ursula, Mühlberger, Nikolai, Conrads-Frank, Annette, Qerimi Rushaj, Vjollca, Sroczynski, Gaby, Koukkou, Eftychia, Thuesen, Betina Heinsbaek, Völzke, Henry, Oberaigner, Wilhelm, Siebert, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849460/
https://www.ncbi.nlm.nih.gov/pubmed/33263563
http://dx.doi.org/10.1530/EC-20-0384
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author Schaffner, Monika
Rochau, Ursula
Mühlberger, Nikolai
Conrads-Frank, Annette
Qerimi Rushaj, Vjollca
Sroczynski, Gaby
Koukkou, Eftychia
Thuesen, Betina Heinsbaek
Völzke, Henry
Oberaigner, Wilhelm
Siebert, Uwe
author_facet Schaffner, Monika
Rochau, Ursula
Mühlberger, Nikolai
Conrads-Frank, Annette
Qerimi Rushaj, Vjollca
Sroczynski, Gaby
Koukkou, Eftychia
Thuesen, Betina Heinsbaek
Völzke, Henry
Oberaigner, Wilhelm
Siebert, Uwe
author_sort Schaffner, Monika
collection PubMed
description OBJECTIVE: More than 30% of the German population suffers from mild to moderate iodine deficiency causing goiter and other iodine deficiency disorders (IDDs). The economic burden of iodine deficiency is still unclear. We aimed to assess costs for prevention, monitoring and treatment of IDDs in Germany. DESIGN: We performed a comprehensive cost analysis. METHODS: We assessed direct medical costs and direct non-medical costs for inpatient and outpatient care of IDDs and costs for productivity loss due to the absence of work in 2018. Additionally, we calculated total costs for an IDD prevention program comprising universal salt iodization (USI). We performed threshold analyses projecting how many cases of IDDs or related treatments would need to be avoided for USI to be cost-saving. RESULTS: Annual average costs per case in the year of diagnosis were € 211 for goiter/thyroid nodules; € 308 for hyperthyroidism; and € 274 for hypothyroidism. Average one-time costs for thyroidectomy were € 4184 and € 3118 for radioiodine therapy. Average costs for one case of spontaneous abortion were € 916. Annual costs of intellectual disability were € 14,202. In the German population, total annual costs for USI would amount to 8 million Euro. To be cost-saving, USI would need to prevent, for example, 37,900 cases of goiter/thyroid nodules. CONCLUSION: USI potentially saves costs, if a minimum amount of IDDs per year could be avoided. In order to recommend the implementation of USI, a full health-economic evaluation including a comprehensive benefit-harm assessment is needed.
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spelling pubmed-78494602021-02-03 The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany Schaffner, Monika Rochau, Ursula Mühlberger, Nikolai Conrads-Frank, Annette Qerimi Rushaj, Vjollca Sroczynski, Gaby Koukkou, Eftychia Thuesen, Betina Heinsbaek Völzke, Henry Oberaigner, Wilhelm Siebert, Uwe Endocr Connect Research OBJECTIVE: More than 30% of the German population suffers from mild to moderate iodine deficiency causing goiter and other iodine deficiency disorders (IDDs). The economic burden of iodine deficiency is still unclear. We aimed to assess costs for prevention, monitoring and treatment of IDDs in Germany. DESIGN: We performed a comprehensive cost analysis. METHODS: We assessed direct medical costs and direct non-medical costs for inpatient and outpatient care of IDDs and costs for productivity loss due to the absence of work in 2018. Additionally, we calculated total costs for an IDD prevention program comprising universal salt iodization (USI). We performed threshold analyses projecting how many cases of IDDs or related treatments would need to be avoided for USI to be cost-saving. RESULTS: Annual average costs per case in the year of diagnosis were € 211 for goiter/thyroid nodules; € 308 for hyperthyroidism; and € 274 for hypothyroidism. Average one-time costs for thyroidectomy were € 4184 and € 3118 for radioiodine therapy. Average costs for one case of spontaneous abortion were € 916. Annual costs of intellectual disability were € 14,202. In the German population, total annual costs for USI would amount to 8 million Euro. To be cost-saving, USI would need to prevent, for example, 37,900 cases of goiter/thyroid nodules. CONCLUSION: USI potentially saves costs, if a minimum amount of IDDs per year could be avoided. In order to recommend the implementation of USI, a full health-economic evaluation including a comprehensive benefit-harm assessment is needed. Bioscientifica Ltd 2020-11-27 /pmc/articles/PMC7849460/ /pubmed/33263563 http://dx.doi.org/10.1530/EC-20-0384 Text en © 2021 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Schaffner, Monika
Rochau, Ursula
Mühlberger, Nikolai
Conrads-Frank, Annette
Qerimi Rushaj, Vjollca
Sroczynski, Gaby
Koukkou, Eftychia
Thuesen, Betina Heinsbaek
Völzke, Henry
Oberaigner, Wilhelm
Siebert, Uwe
The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title_full The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title_fullStr The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title_full_unstemmed The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title_short The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
title_sort economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in germany
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849460/
https://www.ncbi.nlm.nih.gov/pubmed/33263563
http://dx.doi.org/10.1530/EC-20-0384
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