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Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Therapeutic strategies that target leukemic stem cells (LSC) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here we showed that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSC to tyrosine kinase inhibitor (TKI),...

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Detalles Bibliográficos
Autores principales:	Yahata, Takashi, Ibrahim, Abd Aziz, Hirano, Ken-ichi, Muguruma, Yukari, Naka, Kazuhito, Hozumi, Katsuto, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849585/ https://www.ncbi.nlm.nih.gov/pubmed/32001531 http://dx.doi.org/10.3324/haematol.2019.230227

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