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Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activitie...

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Autores principales: Salehi, Bahare, Quispe, Cristina, Chamkhi, Imane, El Omari, Nasreddine, Balahbib, Abdelaali, Sharifi-Rad, Javad, Bouyahya, Abdelhakim, Akram, Muhammad, Iqbal, Mehwish, Docea, Anca Oana, Caruntu, Constantin, Leyva-Gómez, Gerardo, Dey, Abhijit, Martorell, Miquel, Calina, Daniela, López, Víctor, Les, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849684/
https://www.ncbi.nlm.nih.gov/pubmed/33536909
http://dx.doi.org/10.3389/fphar.2020.592654
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author Salehi, Bahare
Quispe, Cristina
Chamkhi, Imane
El Omari, Nasreddine
Balahbib, Abdelaali
Sharifi-Rad, Javad
Bouyahya, Abdelhakim
Akram, Muhammad
Iqbal, Mehwish
Docea, Anca Oana
Caruntu, Constantin
Leyva-Gómez, Gerardo
Dey, Abhijit
Martorell, Miquel
Calina, Daniela
López, Víctor
Les, Francisco
author_facet Salehi, Bahare
Quispe, Cristina
Chamkhi, Imane
El Omari, Nasreddine
Balahbib, Abdelaali
Sharifi-Rad, Javad
Bouyahya, Abdelhakim
Akram, Muhammad
Iqbal, Mehwish
Docea, Anca Oana
Caruntu, Constantin
Leyva-Gómez, Gerardo
Dey, Abhijit
Martorell, Miquel
Calina, Daniela
López, Víctor
Les, Francisco
author_sort Salehi, Bahare
collection PubMed
description Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.
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spelling pubmed-78496842021-02-02 Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence Salehi, Bahare Quispe, Cristina Chamkhi, Imane El Omari, Nasreddine Balahbib, Abdelaali Sharifi-Rad, Javad Bouyahya, Abdelhakim Akram, Muhammad Iqbal, Mehwish Docea, Anca Oana Caruntu, Constantin Leyva-Gómez, Gerardo Dey, Abhijit Martorell, Miquel Calina, Daniela López, Víctor Les, Francisco Front Pharmacol Pharmacology Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules. Frontiers Media S.A. 2021-01-18 /pmc/articles/PMC7849684/ /pubmed/33536909 http://dx.doi.org/10.3389/fphar.2020.592654 Text en Copyright © 2021 Salehi, Quispe, Chamkhi, El Omari, Balahbib, Sharifi-Rad, Bouyahya, Akram, Iqbal, Docea, Caruntu, Leyva-Gómez, Dey, Martorell, Calina, López and Les. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Salehi, Bahare
Quispe, Cristina
Chamkhi, Imane
El Omari, Nasreddine
Balahbib, Abdelaali
Sharifi-Rad, Javad
Bouyahya, Abdelhakim
Akram, Muhammad
Iqbal, Mehwish
Docea, Anca Oana
Caruntu, Constantin
Leyva-Gómez, Gerardo
Dey, Abhijit
Martorell, Miquel
Calina, Daniela
López, Víctor
Les, Francisco
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title_full Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title_fullStr Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title_full_unstemmed Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title_short Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
title_sort pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849684/
https://www.ncbi.nlm.nih.gov/pubmed/33536909
http://dx.doi.org/10.3389/fphar.2020.592654
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