SRC promotes lipogenesis: implications for obesity and breast cancer

Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase Src interacts with and phosphorylates the lip...

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Detalles Bibliográficos
Autores principales: Lin, Shu-Yong, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849727/
https://www.ncbi.nlm.nih.gov/pubmed/33553613
http://dx.doi.org/10.1080/23723556.2020.1866975
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author Lin, Shu-Yong
Lin, Sheng-Cai
author_facet Lin, Shu-Yong
Lin, Sheng-Cai
author_sort Lin, Shu-Yong
collection PubMed
description Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase Src interacts with and phosphorylates the lipogenesis enzyme phosphatidate phosphatase LPIN1 to promote breast cancer development.
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spelling pubmed-78497272021-02-05 SRC promotes lipogenesis: implications for obesity and breast cancer Lin, Shu-Yong Lin, Sheng-Cai Mol Cell Oncol Author’s Views Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase Src interacts with and phosphorylates the lipogenesis enzyme phosphatidate phosphatase LPIN1 to promote breast cancer development. Taylor & Francis 2021-01-12 /pmc/articles/PMC7849727/ /pubmed/33553613 http://dx.doi.org/10.1080/23723556.2020.1866975 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Lin, Shu-Yong
Lin, Sheng-Cai
SRC promotes lipogenesis: implications for obesity and breast cancer
title SRC promotes lipogenesis: implications for obesity and breast cancer
title_full SRC promotes lipogenesis: implications for obesity and breast cancer
title_fullStr SRC promotes lipogenesis: implications for obesity and breast cancer
title_full_unstemmed SRC promotes lipogenesis: implications for obesity and breast cancer
title_short SRC promotes lipogenesis: implications for obesity and breast cancer
title_sort src promotes lipogenesis: implications for obesity and breast cancer
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849727/
https://www.ncbi.nlm.nih.gov/pubmed/33553613
http://dx.doi.org/10.1080/23723556.2020.1866975
work_keys_str_mv AT linshuyong srcpromoteslipogenesisimplicationsforobesityandbreastcancer
AT linshengcai srcpromoteslipogenesisimplicationsforobesityandbreastcancer

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