The pan-cancer lncRNA MILIP links c-Myc to p53 repression

We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver. Our studies show that MILIP facilitates tumor protein p53 (TP53, best known as p53...

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Detalles Bibliográficos
Autores principales: Feng, Yu Chen, Zhao, Xiao Hong, Teng, Liu, Thorne, Rick F., Jin, Lei, Zhang, Xu Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849729/
https://www.ncbi.nlm.nih.gov/pubmed/33553602
http://dx.doi.org/10.1080/23723556.2020.1842714
Descripción
Sumario:We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver. Our studies show that MILIP facilitates tumor protein p53 (TP53, best known as p53) turnover by reducing its SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2), thus promoting cell survival, proliferation, and tumorigenicity. MILIP may thus represent an anti-cancer target for counteracting the c-Myc axis.

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