The pan-cancer lncRNA MILIP links c-Myc to p53 repression

We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver. Our studies show that MILIP facilitates tumor protein p53 (TP53, best known as p53...

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Autores principales: Feng, Yu Chen, Zhao, Xiao Hong, Teng, Liu, Thorne, Rick F., Jin, Lei, Zhang, Xu Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849729/
https://www.ncbi.nlm.nih.gov/pubmed/33553602
http://dx.doi.org/10.1080/23723556.2020.1842714
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author Feng, Yu Chen
Zhao, Xiao Hong
Teng, Liu
Thorne, Rick F.
Jin, Lei
Zhang, Xu Dong
author_facet Feng, Yu Chen
Zhao, Xiao Hong
Teng, Liu
Thorne, Rick F.
Jin, Lei
Zhang, Xu Dong
author_sort Feng, Yu Chen
collection PubMed
description We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver. Our studies show that MILIP facilitates tumor protein p53 (TP53, best known as p53) turnover by reducing its SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2), thus promoting cell survival, proliferation, and tumorigenicity. MILIP may thus represent an anti-cancer target for counteracting the c-Myc axis.
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spelling pubmed-78497292021-02-05 The pan-cancer lncRNA MILIP links c-Myc to p53 repression Feng, Yu Chen Zhao, Xiao Hong Teng, Liu Thorne, Rick F. Jin, Lei Zhang, Xu Dong Mol Cell Oncol Author’s Views We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver. Our studies show that MILIP facilitates tumor protein p53 (TP53, best known as p53) turnover by reducing its SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2), thus promoting cell survival, proliferation, and tumorigenicity. MILIP may thus represent an anti-cancer target for counteracting the c-Myc axis. Taylor & Francis 2020-12-14 /pmc/articles/PMC7849729/ /pubmed/33553602 http://dx.doi.org/10.1080/23723556.2020.1842714 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Feng, Yu Chen
Zhao, Xiao Hong
Teng, Liu
Thorne, Rick F.
Jin, Lei
Zhang, Xu Dong
The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title_full The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title_fullStr The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title_full_unstemmed The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title_short The pan-cancer lncRNA MILIP links c-Myc to p53 repression
title_sort pan-cancer lncrna milip links c-myc to p53 repression
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849729/
https://www.ncbi.nlm.nih.gov/pubmed/33553602
http://dx.doi.org/10.1080/23723556.2020.1842714
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