The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene

The human fetal γ-globin gene is repressed in adulthood through complex regulatory mechanisms involving transcription factors and epigenetic modifiers. Reversing γ-globin repression, or maintaining its expression by manipulating regulatory mechanisms, has become a major clinical goal in the treatmen...

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Detalles Bibliográficos
Autores principales: Fugazza, Cristina, Barbarani, Gloria, Elangovan, Sudharshan, Marini, Maria Giuseppina, Giolitto, Serena, Font-Monclus, Isaura, Marongiu, Maria Franca, Manunza, Laura, Strouboulis, John, Cantu, Claudio, Gasparri, Fabio, Barabino, Silvia M.L., Nakamura, Yukio, Ottolenghi, Sergio, Moi, Paolo, Ronchi, Antonella Ellena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849756/
https://www.ncbi.nlm.nih.gov/pubmed/32107331
http://dx.doi.org/10.3324/haematol.2019.241224

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