C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies

Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that...

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Detalles Bibliográficos
Autores principales: Carabias, Arturo, Guerrero, Carmen, de Pereda, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849780/
https://www.ncbi.nlm.nih.gov/pubmed/33553598
http://dx.doi.org/10.1080/23723556.2020.1837581
Descripción
Sumario:Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.

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