C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies

Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that...

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Autores principales: Carabias, Arturo, Guerrero, Carmen, de Pereda, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849780/
https://www.ncbi.nlm.nih.gov/pubmed/33553598
http://dx.doi.org/10.1080/23723556.2020.1837581
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author Carabias, Arturo
Guerrero, Carmen
de Pereda, José M.
author_facet Carabias, Arturo
Guerrero, Carmen
de Pereda, José M.
author_sort Carabias, Arturo
collection PubMed
description Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.
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spelling pubmed-78497802021-02-05 C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies Carabias, Arturo Guerrero, Carmen de Pereda, José M. Mol Cell Oncol Author’s Views Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells. Taylor & Francis 2020-12-01 /pmc/articles/PMC7849780/ /pubmed/33553598 http://dx.doi.org/10.1080/23723556.2020.1837581 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Carabias, Arturo
Guerrero, Carmen
de Pereda, José M.
C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title_full C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title_fullStr C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title_full_unstemmed C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title_short C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
title_sort c3g self-regulatory mechanism revealed: implications for hematopoietic malignancies
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849780/
https://www.ncbi.nlm.nih.gov/pubmed/33553598
http://dx.doi.org/10.1080/23723556.2020.1837581
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